Priya Gagan
Department of Endocrinology, Fortis Hospital, Mohali, India.
J Pak Med Assoc. 2018 Apr;68(4):669-671.
Prediabetes is an intermediate stage of hyperglycaemia, characterized by impaired fasting glucose, impaired glucose tolerance and/ or an HbA1c ranging from 5.7-6.4%. Prediabetes is associated with an increased risk of progression to overt diabetes and increased risk of cardiovascular disease. Several intervention studies have demonstrated that onset of diabetes can be prevented or delayed with intensive lifestyle modification and oral antidiabetic agents including metformin, thiazolidinediones and alpha-glucosidase inhibitors. Prediabetes management should focus on lifestyle modification and multiple risk factor management. In cases at high risk, use of oral antidiabetic agents may be considered.
糖尿病前期是高血糖的中间阶段，其特征为空腹血糖受损、糖耐量受损和/或糖化血红蛋白（HbA1c）水平在5.7 - 6.4%之间。糖尿病前期与进展为显性糖尿病的风险增加以及心血管疾病风险增加相关。多项干预研究表明，通过强化生活方式改变以及使用包括二甲双胍、噻唑烷二酮类和α-葡萄糖苷酶抑制剂在内的口服抗糖尿病药物，可以预防或延缓糖尿病的发生。糖尿病前期的管理应侧重于生活方式改变和多重危险因素管理。对于高危病例，可考虑使用口服抗糖尿病药物。
