Management of prediabetes.

Prediabetes is an intermediate stage of hyperglycaemia, characterized by impaired fasting glucose, impaired glucose tolerance and/ or an HbA1c ranging from 5.7-6.4%. Prediabetes is associated with an increased risk of progression to overt diabetes and increased risk of cardiovascular disease. Several intervention studies have demonstrated that onset of diabetes can be prevented or delayed with intensive lifestyle modification and oral antidiabetic agents including metformin, thiazolidinediones and alpha-glucosidase inhibitors. Prediabetes management should focus on lifestyle modification and multiple risk factor management. In cases at high risk, use of oral antidiabetic agents may be considered.