Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Department on Aging, Norwegian Institute of Public Health, Oslo, Norway.
Geriatr Gerontol Int. 2018 Aug;18(8):1200-1205. doi: 10.1111/ggi.13447. Epub 2018 May 29.
There is a lack of studies on the prevalence of frailty, and the association between frailty and mortality in a Norwegian general population. Findings regarding sex differences in the association between frailty and mortality have been inconsistent. The aim of the present study was to investigate the association between the frailty phenotype and all-cause mortality in men and women in a Norwegian cohort study.
We followed 712 participants (52% women) aged ≥70 years participating in the population-based Tromsø 5 Study in 2001-2002 for all-cause mortality up to 2016. The frailty status at baseline was defined by a modified version of Fried's frailty criteria. Cox regression models were used to analyze the association between frailty and mortality with adjustment for age, sex, disability, comorbidity, smoking status and years of education.
In total, 3.8% (n = 27) of participants were frail (women 4.4%, men 3.2%) and 38.1% (n = 271) were pre-frail (women 45.8%, men 29.9%). During follow-up (mean 10.1 years), 501 (70%) participants died. We found an increased risk of mortality for frail older adults (multivariable-adjusted HR 4.16, 95% CI 2.40-7.22) compared with non-frail older adults. In sex-stratified analysis, the adjusted HR was 7.09 (95% CI 3.03-16.58) for frail men and 2.93 (95% CI 1.38-6.22) for frail women. Results for pre-frailty showed an overall weaker association with mortality.
While frailty was more prevalent in women than in men, the findings suggest that the association between frailty and mortality is stronger in men than in women. Geriatr Gerontol Int 2018; 18: 1200-1205.
目前缺乏关于挪威普通人群中衰弱流行率以及衰弱与死亡率之间关联的研究。关于衰弱与死亡率之间关联的性别差异的研究结果并不一致。本研究旨在调查挪威队列研究中衰弱表型与男女全因死亡率之间的关联。
我们对 2001-2002 年参与基于人群的特罗姆瑟 5 研究的≥70 岁的 712 名参与者（52%为女性）进行了随访，直至 2016 年全因死亡率。基线时的衰弱状态由弗里德衰弱标准的改良版本定义。使用 Cox 回归模型分析衰弱与死亡率之间的关联，并调整年龄、性别、残疾、合并症、吸烟状况和受教育年限。
共有 3.8%（n=27）的参与者衰弱（女性 4.4%，男性 3.2%），38.1%（n=271）为衰弱前期（女性 45.8%，男性 29.9%）。在随访期间（平均 10.1 年），501 名（70%）参与者死亡。与非衰弱的老年人相比，我们发现衰弱的老年人死亡率风险增加（多变量调整后的 HR 4.16，95%CI 2.40-7.22）。在性别分层分析中，衰弱男性的调整后 HR 为 7.09（95%CI 3.03-16.58），衰弱女性为 2.93（95%CI 1.38-6.22）。衰弱前期与死亡率的关联总体上较弱。
虽然女性的衰弱发生率高于男性，但研究结果表明，衰弱与死亡率之间的关联在男性中强于女性。老年医学与老年病学国际 2018；18：1200-1205。
