四氢异喹啉的多组分合成。
Multicomponent Synthesis of Tetrahydroisoquinolines.
机构信息
Institute of Drug Discovery and Design, College of Pharmaceutical Sciences , Zhejiang University , Hangzhou 310058 , China.
State Key Laboratory of Elemento-Organic Chemistry , Nankai University , Tianjin 300071 , China.
出版信息
Org Lett. 2018 Jun 15;20(12):3460-3464. doi: 10.1021/acs.orglett.8b01159. Epub 2018 May 29.
A multicomponent synthesis of tetrahydroisoquinolines from carboxylic acids, alkynyl ethers, and dihydroisoquinolines is described. This process features readily available starting materials, simple experimental procedures for achievement of molecule complexity, and structural diversity. The preliminary control experiment and crossover reaction provide important insight into the reaction mechanism. The formed tetrahydroisoquinolines could be transformed to an array of compounds.
描述了一种从羧酸、炔基醚和二氢异喹啉出发合成四氢异喹啉的多组分合成方法。该过程具有原料易得、实现分子复杂性和结构多样性的实验步骤简单等特点。初步的对照实验和交叉反应为反应机制提供了重要的见解。形成的四氢异喹啉可以转化为一系列化合物。
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