McCafferty Brandon K, Holleschau Ann M, Connett John E, Summers C Gail
J Pediatr Ophthalmol Strabismus. 2018 Jul 1;55(4):254-259. doi: 10.3928/01913913-20180327-02. Epub 2018 May 29.
To evaluate change in best corrected visual acuity (BCVA) during the second decade of life and the effects of albinism type and extraocular muscle surgery on BCVA in children with albinism.
In this retrospective longitudinal study, 41 patients with albinism with clinic visits recording binocular BCVA at least once between the ages of 10 and 13 years (visit A) and again between the ages of 17 and 20 years (visit B) were included. Type of albinism, age at each visit, and interval eye muscle surgeries were recorded for each patient.
Forty (98%) patients showed BCVA improvement or stability between visits A and B. There was no significant effect of interval extraocular muscle surgery on BCVA. Those carrying either a clinically presumed or moleculary confirmed diagnosis of oculocutaneous albinism types 1B and 2 had the best visual outcomes, consistent with previous studies.
In the majority of patients with albinism, significant improvement in BCVA occurs during the second decade of life. Extraocular muscle surgery was not a significant factor in BCVA improvement in albinism. Overall, the assessments support the finding of improvement of visual acuity in children with albinism at earlier ages and provide new information beneficial in predicting visual outcomes in the second decade of life. [J Pediatr Ophthalmol Strabismus. 2018;55(4):254-259.].
评估白化病患儿在生命的第二个十年中最佳矫正视力（BCVA）的变化，以及白化病类型和眼外肌手术对其BCVA的影响。
在这项回顾性纵向研究中，纳入了41例白化病患者，这些患者在10至13岁之间至少有一次记录双眼BCVA的临床就诊（就诊A），并在17至20岁之间再次就诊（就诊B）。记录每位患者的白化病类型、每次就诊时的年龄以及间隔期眼肌手术情况。
40例（98%）患者在就诊A和就诊B之间BCVA有所改善或保持稳定。间隔期眼外肌手术对BCVA没有显著影响。临床推测或分子确诊为1B型和2型眼皮肤白化病的患者视力预后最佳，这与先前的研究一致。
在大多数白化病患者中，BCVA在生命的第二个十年中显著改善。眼外肌手术不是白化病患者BCVA改善的重要因素。总体而言，这些评估支持了白化病患儿在较早年龄视力改善的发现，并提供了有助于预测生命第二个十年视力预后的新信息。[《小儿眼科与斜视杂志》。2018；55(4)：254 - 259。]
