一名肾移植受者在大肠杆菌败血症后发生的IgA为主的毛细血管外增生性肾小球肾炎。

IgA-dominant extracapillary proliferative glomerulonephritis following Escherichia coli sepsis in a renal transplant recipient.

作者信息

Basic-Jukic Nikolina, Coric Marijana, Kastelan Zeljko

机构信息

Department of Nephrology, Arterial Hypertension Dialysis and Transplantation, School of Medicine, University Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia.

Department of Pathology, School of Medicine, University Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia.

出版信息

Transpl Infect Dis. 2018 Oct;20(5):e12927. doi: 10.1111/tid.12927. Epub 2018 Jun 15.

DOI:10.1111/tid.12927

PMID:29809306

Abstract

Postinfectious glomerulonephritis (PIGN) generally occurs in association with staphylococcal infection. We present the first reported case of IgA-dominant PIGN after Escherichia coli infection in a renal-transplant recipient. A 65-year-old patient with stable allograft function and E. coli urosepsis was treated with ciprofloxacin for 2 weeks with excellent response. One week later he developed proteinuria 16 g/day. Renal biopsy finding revealed IgA-dominant PIGN. He received steroid pulses and intravenous imunoglobulins without effect and had started with hemodialysis.

摘要

感染后肾小球肾炎（PIGN）通常与葡萄球菌感染相关。我们报告了首例肾移植受者在大肠杆菌感染后发生以IgA为主的PIGN病例。一名65岁移植肾功能稳定且患有大肠杆菌脓毒症的患者接受了2周环丙沙星治疗，反应良好。一周后，他出现蛋白尿，每日16克。肾活检结果显示为以IgA为主的PIGN。他接受了类固醇冲击治疗和静脉注射免疫球蛋白，但无效，已开始进行血液透析。