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Hfr formation directed by tn10.由 tn10 指导的高频转导形成。
Genetics. 1979 Apr;91(4):639-55. doi: 10.1093/genetics/91.4.639.
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Spectral and kinetic evidence for two early electron acceptors in photosystem I.光系统I中两个早期电子受体的光谱和动力学证据。
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[The biosynthesis of beta-galactosidase (lactase) in Escherichia coli; the specificity of induction].[大肠杆菌中β-半乳糖苷酶（乳糖酶）的生物合成；诱导的特异性]
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Acetylornithinase of Escherichia coli: partial purification and some properties.大肠杆菌的乙酰鸟氨酸酶：部分纯化及某些性质
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Interaction of cAMP receptor protein with the ompA gene, a gene for a major outer membrane protein of Escherichia coli.环磷酸腺苷受体蛋白与ompA基因的相互作用，ompA基因是大肠杆菌一种主要外膜蛋白的编码基因。
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Isolation of ara-lac gene fusions in Salmonella typhimurium LT2 by using transducing bacteriophage Mu d (Apr lac).利用转导噬菌体Mu d（Apr lac）在鼠伤寒沙门氏菌LT2中分离ara-lac基因融合体。
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Regulation of adenylate cyclase synthesis in Escherichia coli: nucleotide sequence of the control region.大肠杆菌中腺苷酸环化酶合成的调控：控制区的核苷酸序列
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Linkage map of Salmonella typhimurium, Edition VI.鼠伤寒沙门氏菌连锁图谱，第六版。
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Structure of catabolite gene activator protein at 2.9-A resolution. Incorporation of amino acid sequence and interactions with cyclic AMP.2.9埃分辨率下分解代谢物基因激活蛋白的结构。氨基酸序列的整合及与环磷酸腺苷的相互作用。
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鼠伤寒沙门氏菌中环状AMP对cya-lac融合体的调控。

Regulation of a cya-lac fusion by cyclic AMP in Salmonella typhimurium.

作者信息

Jovanovich S B

出版信息

J Bacteriol. 1985 Feb;161(2):641-9. doi: 10.1128/jb.161.2.641-649.1985.

DOI:10.1128/jb.161.2.641-649.1985
PMID:2981819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC214931/
Abstract

cya-lac and crp-lac operon fusions were isolated in Salmonella typhimurium by using the phage Mu d1(lac cts Apr). Both transduction and reversion analyses have indicated that lac expression is controlled by the appropriate promoter, e.g., either crpp or cyap. By using chromosomal mobilization techniques, we found that cya had a clockwise direction of transcription on the standard S. typhimurium map. The cya-lac fusions could be complemented by Escherichia coli F'133, which covers cya, with a resultant 17 to 38% decrease in cya expression. Cyclic AMP was found to be able to repress the expression of the cya-lac fusion ninefold when present at 25 mM. This repression was not seen in crp backgrounds, and hence is mediated by the cAMP receptor protein. Repression of cya was also found upon growth on carbon sources known to elicit high cyclic AMP levels.

摘要

利用噬菌体Mu d1(lac cts Apr)在鼠伤寒沙门氏菌中分离出cya-lac和crp-lac操纵子融合体。转导和回复分析均表明，lac表达受相应启动子控制，例如crpp或cyap。通过染色体迁移技术，我们发现cya在标准鼠伤寒沙门氏菌图谱上转录方向为顺时针。cya-lac融合体可被覆盖cya的大肠杆菌F'133互补，导致cya表达下降17%至38%。发现当环腺苷酸（cAMP）浓度为25 mM时，它能够将cya-lac融合体的表达抑制9倍。在crp背景中未观察到这种抑制作用，因此它是由cAMP受体蛋白介导的。在已知能引发高cAMP水平的碳源上生长时，也发现了对cya的抑制作用。