Suàrez-Güémes F, Collins M T, Whiteman C E
Am J Vet Res. 1985 Jan;46(1):193-201.
Septicemic pasteurellosis (SP) was induced in feedlot lambs. Twenty-eight lambs, randomly allotted into 7 groups, were given combinations of 3 treatments: (i) immunosuppression using hydrocortisone solubilized in dimethyl sulfoxide, (ii) rapid changes in feed, from 100% roughage to 90% concentrate, and (iii) oral inoculation of Pasteurella haemolytica biotype T. Feed changes and immunosuppression by hydrocortisone were needed for the production of SP. Pasteurella haemolytica inoculation was not necessary for induction of SP in all cases, indicating an endogenous source of infection. Clinical pathologic, bacteriologic, and gross and microscopic pathologic findings of induced SP were similar to those described for naturally occurring SP in lambs. Infection of lambs with P haemolytica biotype T via the gastrointestinal tract is discussed as a possible step in the pathogenesis of SP in feedlot lambs.
在育肥牛场的羔羊中诱发了败血性巴氏杆菌病（SP）。将28只羔羊随机分为7组，给予三种处理的组合：（i）使用溶解于二甲基亚砜的氢化可的松进行免疫抑制，（ii）饲料从100%粗饲料快速变为90%精饲料，以及（iii）口服接种溶血巴氏杆菌生物型T。产生SP需要饲料变化和氢化可的松免疫抑制。在所有情况下，接种溶血巴氏杆菌并非诱导SP所必需，这表明存在内源性感染源。诱导性SP的临床病理学、细菌学以及大体和微观病理学发现与羔羊自然发生的SP中所描述的相似。讨论了通过胃肠道用溶血巴氏杆菌生物型T感染羔羊作为育肥牛场羔羊SP发病机制中的一个可能步骤。
