Gomita Y, Gomita H, Nakaebisu H, Kataoka Y, Ueki S
Nihon Yakurigaku Zasshi. 1978 Jul;74(5):615-28. doi: 10.1254/fpj.74.615.
Effects of triazolam on various types of conditioned behavior were investigated and compared mainly with diaepam in rats. The active conditioned avoidance response of the rat in a Shuttle box was inhibited by triazolam and diazepam only at large doses. The passive avoidance response in a step-down method was not affected by either triazolam or diazepam, but was markedly suppressed by chlorpromazine. The low rate response of hypothalamic self-stimulation behavior was markedly increased by triazolam at doses ranging from 2 to 40 mg/kg p.o., but was suppressed at doses over 80 mg/kg p.o. The high rate response was unaffected by triazolam even at doses of 40 approximately 180 mg/kg p.o. The low rate response was increased by diazepam at doses of 1 approximately 10 mg/kg p.o. and was suppressed at 80 mg/kg p.o. The high rate response was reduced by diazepam at 180 mg/kg p.o. In the conflict situation of the rat subjected to food reward and foot-shock punishment, the lever press response in the unpunished period was reduced by triazolam at doses of 1 approximately 5 mg/kg p.o., whereas that in the punished period was markedly increased. Similar effects were observed with diazepam at doses of 15 approximately 20 mg/kg p.o. Triazolam appeared to be 10 approximately 15 times more potent than diazepam in this anticonfluct effect. Thus, triazolam appears to be a potent antianxiety agent.
主要在大鼠中研究并比较了三唑仑对各种类型条件性行为的影响，以及与地西泮的差异。在穿梭箱中，大鼠的主动条件回避反应仅在大剂量时被三唑仑和地西泮抑制。在阶梯式下降法中的被动回避反应不受三唑仑或地西泮的影响，但被氯丙嗪显著抑制。口服剂量为2至40mg/kg时，三唑仑可显著增加下丘脑自我刺激行为的低频率反应，但口服剂量超过80mg/kg时则受到抑制。即使口服剂量为40至180mg/kg，三唑仑对高频率反应也无影响。口服剂量为1至10mg/kg时，地西泮可增加低频率反应，而在80mg/kg时则受到抑制。口服180mg/kg时，地西泮可降低高频率反应。在大鼠接受食物奖励和足部电击惩罚的冲突情境中，口服剂量为1至5mg/kg时，三唑仑可降低未受惩罚期的杠杆按压反应，而在受惩罚期则显著增加。口服剂量为15至20mg/kg时，地西泮也观察到类似效果。在这种抗冲突效应中，三唑仑的效力似乎比地西泮强10至15倍。因此，三唑仑似乎是一种有效的抗焦虑药物。
