多瘤病毒对小鼠胚胎癌细胞多重适应的突变体的分离。
Isolation of polyomavirus mutants multiadapted to murine embryonal carcinoma cells.
作者信息
Melin F, Pinon H, Kress C, Blangy D
出版信息
J Virol. 1985 Mar;53(3):862-6. doi: 10.1128/JVI.53.3.862-866.1985.
Abstract
Polyomavirus mutants were isolated from PCC4 embryonal carcinoma cells infected with a variant strain of polyomavirus (ev 1001h) and were found to contain a tandem duplication overlapping the enhancers and the origin of replication. These mutants were able to infect several lines of embryonal carcinoma cells, including PCC4, F9, and LT1. The sequence and structure of one of these mutants are presented and compared with those of other PyEC PCC4 mutants previously described.
摘要
多瘤病毒突变体是从感染了多瘤病毒变异株（ev 1001h）的PCC4胚胎癌细胞中分离出来的，发现其含有一段与增强子和复制起点重叠的串联重复序列。这些突变体能够感染包括PCC4、F9和LT1在内的多种胚胎癌细胞系。本文展示了其中一个突变体的序列和结构，并与之前描述的其他PyEC PCC4突变体进行了比较。
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