小鼠肿瘤细胞的体外抗原修饰：对自然细胞介导细胞毒性敏感性的影响

Murine in vitro antigenic modification of tumor cells: effect on susceptibility to natural cell-mediated cytotoxicity.

作者信息

Langweiler M, Weinhold K J, Matthews T J, Bolognesi D P

出版信息

J Natl Cancer Inst. 1985 Mar;74(3):699-704.

Abstract

A 3-methylcholanthrene [(MCA) CAS: 56-49-5]-induced fibrosarcoma cell line and its Friend murine leukemia virus-infected counterpart were assessed for their susceptibility to lysis by so-called "natural" effector cells in a series of 51Cr release assays. Detailed functional and phenotypic analysis of lytic effector cell populations from normal C57BL/6 mouse spleens revealed an identity most closely associated with natural cytotoxic cells. Neither tumor cell line was found to be sensitive to natural killer-mediated lysis. Additionally, virus infection of the MCA-induced fibrosarcoma cell line did not affect susceptibility to natural cell-mediated cytotoxicity.

摘要

在一系列51Cr释放试验中，评估了一种3-甲基胆蒽[（MCA），化学物质登记号：56-49-5]诱导的纤维肉瘤细胞系及其感染了弗氏鼠白血病病毒的对应细胞系对所谓“天然”效应细胞裂解的敏感性。对来自正常C57BL/6小鼠脾脏的裂解效应细胞群体进行的详细功能和表型分析显示，其特征与自然细胞毒性细胞最为密切相关。未发现这两种肿瘤细胞系对自然杀伤细胞介导的裂解敏感。此外，MCA诱导的纤维肉瘤细胞系的病毒感染并未影响其对自然细胞介导的细胞毒性的敏感性。

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