Wittert G, Donald R A, Espiner E A, Livesey J H, Fox H
N Z Med J. 1985 Feb 27;98(773):93-7.
The endocrine function of 59 patients with pituitary tumours who were treated in our unit between 1962 and 1982 is reviewed. There were 20 patients with growth hormone (GH) secreting adenomas, 17 with prolactinomas (1 tumour secreted both GH and prolactin), 14 corticotrophin (ACTH) secreting adenomas and nine non-functioning pituitary adenomas. Patients were treated with pituitary surgery and/or irradiation, with and without the addition of drugs. Patients treated with drugs alone were not included. Following combined surgery, radiotherapy and bromocriptine therapy only two acromegalic patients had persistently raised growth hormone levels and five continued to be hyperprolactinaemic. Pituitary irradiation alone was associated with the development of hypothyroidism in three of eight patients. A delayed but significant fall in free thyroxine index (p less than 0.01) was noted in patients receiving 4500 cGy radiotherapy and surgery. Four patients also developed delayed ACTH deficiency at times varying from one to six years after treatment. It is concluded that patients who have received pituitary surgery or irradiation require regular long-term endocrine assessment.
对1962年至1982年间在我院接受治疗的59例垂体瘤患者的内分泌功能进行了回顾性研究。其中生长激素（GH）分泌性腺瘤患者20例，催乳素瘤患者17例（1例肿瘤同时分泌GH和催乳素），促肾上腺皮质激素（ACTH）分泌性腺瘤患者14例，无功能性垂体腺瘤患者9例。患者接受了垂体手术和/或放疗，部分患者加用了药物。未纳入仅接受药物治疗的患者。在联合手术、放疗和溴隐亭治疗后，仅有2例肢端肥大症患者的生长激素水平持续升高，5例患者仍有高催乳素血症。单独垂体放疗的8例患者中有3例发生了甲状腺功能减退。接受4500 cGy放疗和手术的患者，其游离甲状腺素指数出现延迟但显著下降（p<0.01）。4例患者在治疗后1至6年出现延迟性ACTH缺乏。结论是，接受垂体手术或放疗的患者需要定期进行长期内分泌评估。
