从患有遗传性运动终板疾病的动物分离出的神经肌肉制剂中瘫痪的逆转。
Reversal of paralysis in nerve-muscle preparations isolated from animals with hereditary motor endplate disease.
作者信息
Harris J B, Pollard S L
出版信息
Br J Pharmacol. 1985 Jan;84(1):6-8.
Abstract
Motor endplate disease (med) in the mouse is an hereditary disorder of the skeletal neuromuscular system. Affected animals suffer a 'functional denervation' of skeletal muscle (Duchen & Stefani, 1971). Muscle fibres do not respond to indirect excitation, but motor nerve terminals release transmitter spontaneously. Spontaneous transmitter release can be enhanced by raising [K+]o or by exposing muscles to red-back spider venom and functional transmission following indirect stimulation may be restored by 4-aminopyridine.
摘要
小鼠的运动终板病（med）是一种骨骼肌神经肌肉系统的遗传性疾病。患病动物的骨骼肌会出现“功能性去神经支配”（杜兴和斯特凡尼，1971年）。肌纤维对间接刺激无反应，但运动神经末梢会自发释放递质。提高细胞外钾离子浓度（[K+]o）或使肌肉暴露于红背蜘蛛毒液中可增强递质的自发释放，而间接刺激后的功能性传递可通过4-氨基吡啶恢复。
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