血管活性肠肽与双相情感障碍。锂盐作用的证据。

Vasoactive intestinal peptide and bipolar affective illness. Evidence for an effect of lithium.

作者信息

Berrettini W H, Nurnberger J I, Hotvedt P, Simmons-Alling S, Gershon E S

出版信息

J Affect Disord. 1985 Jan-Feb;8(1):55-9. doi: 10.1016/0165-0327(85)90072-2.

Abstract

In an attempt to evaluate the role of VIP in affective disorder, measurements of lymphocyte VIP receptors, and plasma and CSF VIP levels were made in unmedicated and lithium-treated euthymic bipolars and controls. Lithium decreased plasma (P = 0.01) and CSF (P = 0.05) VIP levels and increased the affinity (decreased the KD) of the VIP lymphocyte receptor (P less than 0.01). This effect may be relevant to the psychotropic action of lithium in manic-depressive illness.

摘要

为了评估血管活性肠肽（VIP）在情感障碍中的作用，对未用药及接受锂盐治疗的心境正常的双相情感障碍患者和对照组进行了淋巴细胞VIP受体、血浆及脑脊液VIP水平的测定。锂盐降低了血浆（P = 0.01）和脑脊液（P = 0.05）中的VIP水平，并增加了VIP淋巴细胞受体的亲和力（降低了解离常数KD）（P < 0.01）。这种效应可能与锂盐在躁狂抑郁症中的精神药理作用有关。