AMPA 受体复合物组成成分：对受体组装、膜运输和亚细胞定位的控制。
AMPA receptor complex constituents: Control of receptor assembly, membrane trafficking and subcellular localization.
机构信息
Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
出版信息
Mol Cell Neurosci. 2018 Sep;91:67-75. doi: 10.1016/j.mcn.2018.05.008. Epub 2018 May 26.
Fast excitatory transmission at synapses of the central nervous system is mainly mediated by AMPA receptors (AMPARs). Synaptic AMPAR number and function correlates with synaptic strength. AMPARs are thus key proteins of activity-dependent plasticity in neuronal communication. Up- or down-regulation of synaptic AMPAR number is a tightly controlled dynamic process that involves export of receptors from the endoplasmic reticulum (ER) and Golgi apparatus, exocytosis and endocytosis as well as lateral diffusion of the receptors in the cell membrane. The four AMPAR subunits are embedded into a dynamic network of more than 30 interacting proteins. Many of these proteins are known to modulate receptor gating, trafficking and subcellular localization. Here, we will review the influence that AMPAR interacting proteins exert on trafficking and subcellular localization of the receptors by controlling their assembly, ER/Golgi apparatus export, and synaptic anchoring.
快速兴奋传递在中枢神经系统的突触主要通过 AMPA 受体（AMPARs）介导。突触 AMPAR 的数量和功能与突触强度相关。因此，AMPAR 是神经元通讯中活动依赖性可塑性的关键蛋白。突触 AMPAR 数量的上调或下调是一个受严格控制的动态过程，涉及受体从内质网（ER）和高尔基体的输出、胞吐作用和胞吞作用以及质膜中受体的侧向扩散。这四个 AMPAR 亚基嵌入到一个由 30 多种相互作用蛋白组成的动态网络中。许多这些蛋白被认为调节受体门控、运输和亚细胞定位。在这里，我们将通过控制它们的组装、ER/高尔基体输出和突触锚定来综述 AMPAR 相互作用蛋白对受体运输和亚细胞定位的影响。
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