血小板平均体积降低与食管癌预后不良相关。
Reduced mean platelet volume is associated with poor prognosis in esophageal cancer.
机构信息
Department of Gynaecology and Obstetrics, First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, Heilongjiang, China.
出版信息
Cancer Biomark. 2018;22(3):559-563. doi: 10.3233/CBM-181231.
BACKGROUND
Esophageal cancer (EC) is the sixth most common cause of death from cancer. Altered mean platelet volume (MPV) levels were found in patients with malignancies.
OBJECTIVE
The present study investigated whether MPV can predict the survival in EC patients.
MEHTODS
The clinical data of 236 consecutive EC patients between January 2009 and December 2009 in our center were retrospectively analyzed. The overall survival rate was estimated using Kaplan-Meier method. Cox proportional hazards models were fitted to model the relationships between patient characteristics and prognosis.
RESULTS
Decreased MPV was significantly correlated with tumor location and tumor differentiation (p< 0.001). Moreover, survival analysis revealed that the overall survival of patients with MPV ⩽ 7.4 fL was significantly shorter than that of those with MPV > 7.4 fL. Multivariate analysis identified MPV as an independent poor prognostic factor for overall survival.
CONCLUSIONS
Reduced MPV is associated with worse survival outcome in EC.
背景
食管癌（EC）是癌症死亡的第六大主要原因。恶性肿瘤患者的平均血小板体积（MPV）水平发生改变。
目的
本研究旨在探讨MPV 是否可预测 EC 患者的生存情况。
方法
回顾性分析 2009 年 1 月至 2009 年 12 月在我院就诊的 236 例连续 EC 患者的临床资料。采用 Kaplan-Meier 法估计总生存率。采用 Cox 比例风险模型来分析患者特征与预后之间的关系。
结果
MPV 降低与肿瘤位置和肿瘤分化程度显著相关（p<0.001）。此外，生存分析显示，MPV ⩽7.4 fL 的患者的总生存率明显短于MPV >7.4 fL 的患者。多因素分析确定 MPV 是总生存的独立预后不良因素。
结论
MPV 降低与 EC 的生存结局不良相关。
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