Department of Ear, Nose & Throat, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, 325027, Wenzhou, Zhejiang, 325027, China.
Clinical Laboratory Center, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Biomark Med. 2021 Feb;15(3):157-166. doi: 10.2217/bmm-2020-0203. Epub 2021 Jan 21.
This study aimed to evaluate the clinical values of platelet parameters in patients with digestive tumors. A total of 974 people were classified into three groups: malignant group, patients with digestive malignant tumors; benign group, patients with benign tumors; and normal group: healthy individuals. Compared with the benign and normal groups, the malignant group showed significantly increased platelet count (PLT) and plateletcrit (PCT) and significantly reduced mean platelet volume (MPV) and platelet-large cell rate (P-LCR, p < 0.001). Elevated PLT and PCT and reduced MPV and P-LCR indicated poor overall survival in patients with digestive tumors. PLT, PCT, MPV and P-LCR were proven to be predictive biomarkers for patients with digestive malignant tumors. Elevated PLT and PCT or decreased MPV and P-LCR indicated poor overall survival.
本研究旨在评估血小板参数在消化道肿瘤患者中的临床价值。共纳入 974 例患者，分为三组：恶性组，患有消化道恶性肿瘤的患者；良性组，患有良性肿瘤的患者；和正常组：健康个体。与良性组和正常组相比，恶性组的血小板计数（PLT）和血小板压积（PCT）显著升高，平均血小板体积（MPV）和血小板大细胞比率（P-LCR）显著降低（p<0.001）。升高的 PLT 和 PCT 以及降低的 MPV 和 P-LCR 表明消化道肿瘤患者的总生存率较差。PLT、PCT、MPV 和 P-LCR 被证明是消化道恶性肿瘤患者的预测生物标志物。升高的 PLT 和 PCT 或降低的 MPV 和 P-LCR 表明总生存率较差。
