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消化肿瘤的经济且易于检测的标志物:血小板参数。

Economical and easily detectable markers of digestive tumors: platelet parameters.

机构信息

Department of Ear, Nose & Throat, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, 325027, Wenzhou, Zhejiang, 325027, China.

Clinical Laboratory Center, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.

出版信息

Biomark Med. 2021 Feb;15(3):157-166. doi: 10.2217/bmm-2020-0203. Epub 2021 Jan 21.

Abstract

This study aimed to evaluate the clinical values of platelet parameters in patients with digestive tumors. A total of 974 people were classified into three groups: malignant group, patients with digestive malignant tumors; benign group, patients with benign tumors; and normal group: healthy individuals. Compared with the benign and normal groups, the malignant group showed significantly increased platelet count (PLT) and plateletcrit (PCT) and significantly reduced mean platelet volume (MPV) and platelet-large cell rate (P-LCR, p < 0.001). Elevated PLT and PCT and reduced MPV and P-LCR indicated poor overall survival in patients with digestive tumors. PLT, PCT, MPV and P-LCR were proven to be predictive biomarkers for patients with digestive malignant tumors. Elevated PLT and PCT or decreased MPV and P-LCR indicated poor overall survival.

摘要

本研究旨在评估血小板参数在消化道肿瘤患者中的临床价值。共纳入 974 例患者,分为三组:恶性组,患有消化道恶性肿瘤的患者;良性组,患有良性肿瘤的患者;和正常组:健康个体。与良性组和正常组相比,恶性组的血小板计数(PLT)和血小板压积(PCT)显著升高,平均血小板体积(MPV)和血小板大细胞比率(P-LCR)显著降低(p<0.001)。升高的 PLT 和 PCT 以及降低的 MPV 和 P-LCR 表明消化道肿瘤患者的总生存率较差。PLT、PCT、MPV 和 P-LCR 被证明是消化道恶性肿瘤患者的预测生物标志物。升高的 PLT 和 PCT 或降低的 MPV 和 P-LCR 表明总生存率较差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8323/7857339/2eb1ce7036bc/bmm-15-157-g1.jpg

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