咪达唑仑在杏仁核中的抗冲突作用是由特定的苯二氮䓬受体介导的证据。
Evidence that the anticonflict effect of midazolam in amygdala is mediated by the specific benzodiazepine receptors.
作者信息
Petersen E N, Braestrup C, Scheel-Krüger J
出版信息
Neurosci Lett. 1985 Feb 4;53(3):285-8. doi: 10.1016/0304-3940(85)90552-x.
The benzodiazepine midazolam produced an anticonflict effect in rats measured in a water lick paradigm following local injection into the basolateral and lateral complex of the amygdala. This effect of midazolam seems to involve specific benzodiazepine receptors, since the systemic injection of benzodiazepine antagonists Ro 15-1788, ZK 93426, FG 7142 and CGS 8216 produced strong antagonism of the effect of midazolam in doses not affecting the non-punished drinking behaviour.
在大鼠的水舔范式中，通过向杏仁核基底外侧和外侧复合体局部注射苯二氮䓬类药物咪达唑仑，可产生抗冲突效应。咪达唑仑的这种效应似乎涉及特定的苯二氮䓬受体，因为全身注射苯二氮䓬拮抗剂Ro 15 - 1788、ZK 93426、FG 7142和CGS 8216，在不影响非惩罚性饮水行为的剂量下，对咪达唑仑的效应产生了强烈拮抗作用。
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