惊厥性苯二氮䓬类药物和GABA拮抗剂Ro 5-3663以及苯二氮䓬受体拮抗剂Ro 15-1788的行为学研究
A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788.
作者信息
Feldon J, Lerner T, Levin D, Myslobodsky M
出版信息
Pharmacol Biochem Behav. 1983 Jul;19(1):39-41. doi: 10.1016/0091-3057(83)90308-8.
The potential "anxiogenic" effects of convulsant benzodiazepine and GABA-antagonist, Ro 5-3663 and specific antagonist of benzodiazepine receptors, Ro 15-1788 were compared in the Geller-Seifter conflict paradigm. Chlordiazepoxide (CDP) (5 mg/kg) was used as a "positive" control. Both Ro 5-3663 (1 mg/kg) and Ro 15-1788 (10 mg/kg) antagonized the anticonflict effect of CDP. However, while Ro 15-1788 had a modest anticonflict potency. Ro 5-3663 had an anxiogenic effect in its own right.
在盖勒-西弗冲突范式中，比较了惊厥性苯二氮䓬和GABA拮抗剂Ro 5-3663以及苯二氮䓬受体特异性拮抗剂Ro 15-1788的潜在“致焦虑”作用。氯氮卓（CDP）（5毫克/千克）用作“阳性”对照。Ro 5-3663（1毫克/千克）和Ro 15-1788（10毫克/千克）均拮抗了CDP的抗冲突作用。然而，虽然Ro 15-1788具有适度的抗冲突效力，但Ro 5-3663本身具有致焦虑作用。
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