Bartley J A, Ward R
Pediatr Res. 1985 Mar;19(3):313-4. doi: 10.1203/00006450-198503000-00012.
Glycerol 3-phosphate is an initial metabolite in the biosynthesis of phosphoglycerides and triacylglycerols. Both glycerol and glucose are precursors of glycerol 3-phosphate. Cultured skin fibroblasts from patients with glycerol kinase deficiency utilized glucose, but not glycerol in the biosynthesis of phosphoglycerides and triacylglycerols. Phosphoglyceride and triacylglycerol biosynthesis in glycerol kinase deficiency fibroblasts is not diminished by the inability to use glycerol as a precursor of glycerol 3-phosphate.
3-磷酸甘油是磷脂和三酰甘油生物合成中的初始代谢物。甘油和葡萄糖都是3-磷酸甘油的前体。来自甘油激酶缺乏症患者的培养皮肤成纤维细胞在磷脂和三酰甘油的生物合成中利用葡萄糖，但不利用甘油。甘油激酶缺乏的成纤维细胞中磷脂和三酰甘油的生物合成不会因无法使用甘油作为3-磷酸甘油的前体而减少。
