使用溴隐亭使促肾上腺皮质激素依赖性库欣综合征缓解六年
Six year remission of ACTH-dependent Cushing's syndrome using bromocriptine.
作者信息
Atkinson A B, Kennedy A L, Sheridan B
出版信息
Postgrad Med J. 1985 Mar;61(713):239-42. doi: 10.1136/pgmj.61.713.239.
Abstract
A patient with ACTH-dependent Cushing's syndrome remained in clinical and biochemical remission six years after pituitary irradiation and while on bromocriptine therapy. When bromocriptine was discontinued urinary free cortisol values became elevated, and were not suppressed by dexamethasone. After reintroduction of the drug, remission was again obtained. It is concluded that bromocriptine is responsible for continuing longterm remission in this case. The possible use of bromocriptine as an adjunctive therapy in ACTH-dependent Cushing's syndrome is discussed.
摘要
一名促肾上腺皮质激素（ACTH）依赖型库欣综合征患者在垂体放疗并接受溴隐亭治疗后六年，仍处于临床和生化缓解状态。停用溴隐亭后，尿游离皮质醇值升高，且地塞米松不能抑制其升高。重新使用该药物后，再次获得缓解。得出的结论是，在这种情况下，溴隐亭是导致长期持续缓解的原因。文中讨论了溴隐亭作为ACTH依赖型库欣综合征辅助治疗药物的可能用途。
相似文献
1
Six year remission of ACTH-dependent Cushing's syndrome using bromocriptine.使用溴隐亭使促肾上腺皮质激素依赖性库欣综合征缓解六年
Postgrad Med J. 1985 Mar;61(713):239-42. doi: 10.1136/pgmj.61.713.239.
2
ACTH and cortisol response to bromocriptine, and results of long-term therapy, in Cushing's disease.
Acta Endocrinol (Copenh). 1978 Nov;89(3):461-8. doi: 10.1530/acta.0.0890461.
3
Cortisol-suppressible dexamethasone-nonsuppressible cyclic Cushing's disease with evidence of clinical and biochemical remission with bromocriptine.可被皮质醇抑制、地塞米松不抑制的周期性库欣病，有证据表明溴隐亭治疗后临床及生化指标缓解
Endocrinol Jpn. 1991 Jun;38(3):315-24. doi: 10.1507/endocrj1954.38.315.
4
Cyclic Cushing's disease in long-term remission with a daily low dose of bromocriptine.长期缓解的周期性库欣病采用每日低剂量溴隐亭治疗
Intern Med. 1996 Mar;35(3):207-11. doi: 10.2169/internalmedicine.35.207.
5
Reduction of pituitary tumor size with clinical and biochemical improvement with bromocriptine in a normoprolactinemic Cushing's disease.在一名催乳素正常的库欣病患者中，溴隐亭使垂体肿瘤缩小，临床症状和生化指标改善。
Endocrinol Jpn. 1990 Dec;37(6):875-82. doi: 10.1507/endocrj1954.37.875.
6
A case of Cushing's disease successfully treated with bromocriptine.
Jpn J Med. 1990 Mar-Apr;29(2):185-90. doi: 10.2169/internalmedicine1962.29.185.
7
Effect of bromocriptine in pituitary-dependent Cushing's syndrome.溴隐亭对垂体依赖性库欣综合征的作用。
Clin Endocrinol (Oxf). 1983 Oct;19(4):485-91. doi: 10.1111/j.1365-2265.1983.tb00023.x.
8
Long term bromocriptine therapy in Cushing's disease.库欣病的长期溴隐亭治疗
J Endocrinol Invest. 1982 Mar-Apr;5(2):117-20. doi: 10.1007/BF03350502.
9
Lack of effect of bromocriptine on ACTH levels in patients with bilateral adrenalectomy for pituitary-dependent Cushing's syndrome.
J Endocrinol Invest. 1978 Oct;1(4):355-7. doi: 10.1007/BF03350982.
10
Cushing's disease: clinical and laboratory response to bromocriptine therapy.库欣病：对溴隐亭治疗的临床及实验室反应
J Endocrinol Invest. 1984 Dec;7(6):585-8. doi: 10.1007/BF03349490.
引用本文的文献
1
Role of "old" pharmacological agents in the treatment of Cushing's syndrome.“老”药在库欣综合征治疗中的作用。
J Endocrinol Invest. 2016 Sep;39(9):957-65. doi: 10.1007/s40618-016-0462-4. Epub 2016 Apr 16.
2
Dopamine D2 receptor gene expression in human adenohypophysial adenomas.人腺垂体腺瘤中多巴胺D2受体基因的表达
Endocrine. 2001 Apr;14(3):329-36. doi: 10.1385/endo:14:3:329.
本文引用的文献
1
A survey of results with transsphenoidal surgery in Cushing's disease.
N Engl J Med. 1983 Jan 13;308(2):103-4. doi: 10.1056/NEJM198301133080216.
2
Adrenocorticotropin and cortisol responsiveness to thyrotropin-releasing hormone and luteinizing hormone-releasing hormone discloses two subsets of patients with Cushing's disease.促肾上腺皮质激素和皮质醇对促甲状腺激素释放激素和促黄体生成素释放激素的反应性揭示了库欣病患者的两个亚组。
J Clin Endocrinol Metab. 1982 Dec;55(6):1188-97. doi: 10.1210/jcem-55-6-1188.
3
Long term bromocriptine therapy in Cushing's disease.库欣病的长期溴隐亭治疗
J Endocrinol Invest. 1982 Mar-Apr;5(2):117-20. doi: 10.1007/BF03350502.
4
Adrenocorticotropin-secreting pituitary adenomas originate from the anterior or the intermediate lobe in Cushing's disease: differences in the regulation of hormone secretion.促肾上腺皮质激素分泌型垂体腺瘤起源于库欣病患者的垂体前叶或中间叶：激素分泌调节的差异
J Clin Endocrinol Metab. 1982 Feb;54(2):286-91. doi: 10.1210/jcem-54-2-286.
5
The mechanism of the suppressive action of bromocriptine on adrenocorticotropin secretion in patients with Cushing's disease and Nelson's syndrome.溴隐亭对库欣病和尼尔森综合征患者促肾上腺皮质激素分泌的抑制作用机制。
J Clin Endocrinol Metab. 1980 Aug;51(2):307-11. doi: 10.1210/jcem-51-2-307.
6
Spontaneous remission of Cushing's disease. Report of a case.库欣病的自发缓解。病例报告。
N Engl J Med. 1967 Apr 27;276(17):968-70. doi: 10.1056/NEJM196704272761708.
7
DNA synthesis and the secretion of prolactin and growth hormone by the pituitary gland of the male rat: effects of diethylstilboestrol and 2-bromo-alpha-ergocryptine methanesluphonate.雄性大鼠垂体的DNA合成以及催乳素和生长激素的分泌：己烯雌酚和2-溴-α-麦角隐亭甲磺酸盐的作用
J Endocrinol. 1974 Jun;61(3):411-7. doi: 10.1677/joe.0.0610411.
8
Cyproheptadine-induced remission of Cushing's disease.赛庚啶诱导库欣病缓解
N Engl J Med. 1975 Oct 30;293(18):893-6. doi: 10.1056/NEJM197510302931802.
9
Effects of oestrogen and bromocryptine on in vivo secretion and mitosis in prolactin cells.
Nature. 1975 Jun 5;255(5508):497-8. doi: 10.1038/255497a0.
10
Bromocriptine and endocrine disorders.
Ann Intern Med. 1979 Jun;90(6):949-56. doi: 10.7326/0003-4819-90-6-949.
Zotero 插件