Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang, Korea.
J Clin Endocrinol Metab. 2018 Aug 1;103(8):3103-3109. doi: 10.1210/jc.2018-00717.
The results of a previous population cohort study suggested an association between osteoporosis and sudden sensory neural hearing loss (SSNHL).
To use a nationwide cohort in the Korean population to investigate the risk of SSNHL in patients with osteoporosis.
DESIGN, SETTING, AND PARTICIPANTS: Data entered from 2002 to 2013 were collected from the Korean National Health Insurance Service-National Sample Cohort. A total of 68,241 patients with osteoporosis aged ≥50 years were matched with 68,241 control individuals. The crude (simple) and adjusted hazard ratios (HRs) of SSNHL in those with osteoporosis were analyzed using the Cox proportional hazard model. A subgroup analysis was performed according to age and sex.
The risk of SSNHL was greater in the osteoporosis group than in the control group (adjusted HR, 1.56; 95% CI, 1.37 to 1.78; P < 0.001). The risk of SSNHL in those with osteoporosis was greater in patients aged <60 years, regardless of sex. Women aged ≥60 years had a higher HR for SSNHL in the presence of osteoporosis (women aged 60 to 69 years: adjusted HR, 1.67; 95% CI, 1.34 to 2.08; P < 0.001; women aged ≥70 years: adjusted HR, 1.90; 95% CI, 1.29 to 2.79; P < 0.001).
The risk of SSNHL was greater for patients with osteoporosis aged ≥50 years. Middle-age adults, as well as the elderly, are at an increased risk of SSNHL in the presence of osteoporosis.
先前的一项人群队列研究结果表明，骨质疏松症与突发性感觉神经性听力损失（SSNHL）之间存在关联。
使用韩国人群的全国性队列研究调查骨质疏松症患者发生 SSNHL 的风险。
设计、地点和参与者：2002 年至 2013 年的数据来自韩国国民健康保险服务-国家样本队列。共纳入 68241 例年龄≥50 岁的骨质疏松症患者，并与 68241 名对照个体进行匹配。使用 Cox 比例风险模型分析骨质疏松症患者发生 SSNHL 的粗（简单）和调整后风险比（HR）。根据年龄和性别进行亚组分析。
与对照组相比，骨质疏松症组发生 SSNHL 的风险更高（调整后 HR，1.56；95%CI，1.37 至 1.78；P<0.001）。无论性别如何，年龄<60 岁的骨质疏松症患者发生 SSNHL 的风险更高。年龄≥60 岁的女性在患有骨质疏松症时发生 SSNHL 的 HR 更高（60 至 69 岁女性：调整后 HR，1.67；95%CI，1.34 至 2.08；P<0.001；≥70 岁女性：调整后 HR，1.90；95%CI，1.29 至 2.79；P<0.001）。
年龄≥50 岁的骨质疏松症患者发生 SSNHL 的风险更高。中老年人在患有骨质疏松症时，发生 SSNHL 的风险增加。
