Yeh Mei-Chen, Weng Shih-Feng, Shen Yuan-Chi, Chou Chien-Wen, Yang Chwen-Yi, Wang Jhi-Joung, Tien Kai-Jen
Division of Endocrinology and Metabolism, Department of Internal Medicine (M.C.Y., C.W.C., C.Y.Y., K.J.T.), and Department of Medical Research (S.F.W., J.J.W.), Chi Mei Medical Center, Tainan, Taiwan; Department of Healthcare Administration and Medical Informatics (S.F.W.), Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Urology (Y.C.S.), Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Cheng Shiu University (Y.C.S.), Kaohsiung, Taiwan; and Department of Senior Citizen Service Management (K.J.T.), Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
J Clin Endocrinol Metab. 2015 Jun;100(6):2413-9. doi: 10.1210/jc.2014-4316. Epub 2015 Apr 16.
Previous studies have reported an increased prevalence of sudden sensorineural hearing loss (SSNHL) in osteoporotic patients. However, the risk of SSNHL in this population remains unclear.
This study investigated the risk of SSNHL in osteoporotic patients.
Taiwan launched a single-payer National Health Insurance (NHI) program on March 1, 1995. NHI covers nearly all of Taiwan's residents.
Using randomized representative sample of one million individuals from Taiwan's National Health Insurance claims database, we compared the data of 10,660 patients with newly diagnosed osteoporosis from 1998-2008 and with 31,980 patients without osteoporosis. All patients were tracked until SSNHL was diagnosed, death, or the end of 2011. Osteoporosis was identified based on a primary diagnosis of osteoporosis (ICD-9-CM code 7330) by dual-energy x-ray absorptiometry.
Identified the diagnosis of osteoporosis and SSNHL by ICD-9CM code.
The identification of patients with newly diagnosed SSNHL by ICD-9CM code.
The incidence rates of SSNHL in the osteoporosis cohort and comparison group were 10.43 and 5.93 per 10,000 person years. Patients with osteoporosis were at 1.76 times the risk of developing SSNHL than patients without osteoporosis. The incidence rate ratio (IRR) for SSNHL was significantly greater in older (50-64 y and ≥ 65 y), and female patients, and borderline greater in hypertensive patients with osteoporosis than the controls, IRRs being 1.50, 2.33, 1.87, and 1.59.
Patients with osteoporosis are at significantly greater risk of developing SSNHL.
既往研究报告称骨质疏松症患者中突发性感音神经性听力损失（SSNHL）的患病率有所增加。然而，该人群中SSNHL的风险仍不明确。
本研究调查骨质疏松症患者发生SSNHL的风险。
台湾于1995年3月1日启动了单一支付者的全民健康保险（NHI）计划。NHI覆盖了几乎所有台湾居民。
利用来自台湾全民健康保险理赔数据库的100万个体的随机代表性样本，我们比较了1998年至2008年新诊断为骨质疏松症的10660例患者和31980例无骨质疏松症患者的数据。所有患者均被跟踪直至诊断出SSNHL、死亡或2011年底。骨质疏松症通过双能X线吸收法根据骨质疏松症的初步诊断（ICD-9-CM编码7330）确定。
通过ICD-9-CM编码确定骨质疏松症和SSNHL的诊断。
通过ICD-9-CM编码识别新诊断为SSNHL的患者。
骨质疏松症队列和对照组中SSNHL的发病率分别为每10000人年10.43例和5.93例。骨质疏松症患者发生SSNHL的风险是无骨质疏松症患者的1.76倍。SSNHL的发病率比（IRR）在年龄较大（50-64岁和≥65岁）的女性患者中显著更高，而骨质疏松症高血压患者的IRR比对照组略高，分别为1.50、2.33、1.87和1.59。
骨质疏松症患者发生SSNHL的风险显著更高。
