a Sydney School of Public Health, Sydney Medical School , University of Sydney , Sydney , Australia.
Expert Rev Anticancer Ther. 2018 Aug;18(8):785-791. doi: 10.1080/14737140.2018.1483243. Epub 2018 Jun 7.
Digital breast tomosynthesis (DBT) addresses some of the limitations of digital mammography (DM) by reducing the effect of overlapping tissue. Emerging data have shown that DBT increases breast cancer (BC) detection and reduces recall in BC screening programs. Studies have also suggested that DBT improves assessment of screen-recalled findings. Areas covered: Studies of DBT for population BC screening and those for assessment of screen-detected findings were reviewed to provide an up-to-date summary of the evidence on DBT in the screening setting. A systematic literature search was conducted for each of the topics; study-specific information and/or quantitative data on detection or accuracy were extracted and collated in tables. Expert commentary: The evidence on DBT for BC screening reinforces that DBT integrated with DM increases cancer detection rates compared to DM alone, although the extent of improved detection varied between studies. The effect of DBT on recall rates was heterogeneous with substantial reductions evident noticeably in retrospective comparative studies. The evidence on DBT for workup was sparse and those studies had limitations related to design and methods. Even though the majority showed improved specificity using DBT compared with conventional imaging, there was little evidence on how DBT impacts assessment outcomes.
数字乳腺断层合成术（DBT）通过减少重叠组织的影响，解决了数字乳腺摄影术（DM）的一些局限性。新出现的数据表明，DBT 提高了乳腺癌（BC）的检出率，并降低了 BC 筛查计划中的召回率。研究还表明，DBT 改善了对筛查召回发现的评估。涵盖领域：对用于人群 BC 筛查的 DBT 研究和用于评估筛查发现的 DBT 研究进行了回顾，以提供有关 DBT 在筛查环境中的最新证据总结。针对每个主题进行了系统的文献检索；提取并汇总了研究特定信息和/或关于检测或准确性的定量数据。专家评论：DBT 用于 BC 筛查的证据证实，与单独使用 DM 相比，DBT 与 DM 联合使用可提高癌症检出率，尽管不同研究之间的检出率提高程度有所不同。DBT 对召回率的影响是不均匀的，在明显的回顾性比较研究中明显降低。关于 DBT 用于工作流程的证据很少，这些研究在设计和方法上存在局限性。尽管大多数研究显示与常规成像相比，使用 DBT 可提高特异性，但几乎没有证据表明 DBT 如何影响评估结果。
