Department of Food Science and Dietetics, Wrocław Medical University, Borowska 211, 50-556 Wrocław, Poland.
Diagnostics Laboratory for Teaching and Research, Wrocław Medical University, Borowska 211, 50-556 Wrocław, Poland.
Oxid Med Cell Longev. 2018 Apr 5;2018:8506343. doi: 10.1155/2018/8506343. eCollection 2018.
A direct contribution towards destructive, proliferative synovitis in rheumatoid arthritis (RA) has been attributed to reactive oxygen species action. Some nutrients are considered to be capable of improving the oxidant/antioxidant status in RA; however the impact of diet composition on the antioxidant capacity of serum has not yet been studied in this disease. The aim of the study was to assess the relationship between diet quality and antioxidant status in patients with RA and healthy controls. Nutritional assessment was performed, and antioxidant status in serum, without and with deproteinization (TAS and DSAS, resp.), was determined in 82 RA and 87 healthy subjects. The diet of the RA group was low-energy and imbalanced. TAS and DSAS were significantly lower in RA patients than in controls. Antioxidant status significantly correlated with the supply of foods and nutrients influencing antioxidant and anti-inflammatory defense in RA; however, in this group, TAS was more sensitive to diet than DSAS. In healthy subjects, the nonprotein pool of serum antioxidants was more tightly linked to diet. These outcomes indicate the need to monitor diet quality of patients with RA and the usefulness of TAS measurements in this monitoring.
活性氧（reactive oxygen species）的作用被认为是导致类风湿关节炎（rheumatoid arthritis，RA）破坏性、增殖性滑膜炎的一个直接因素。一些营养素被认为能够改善 RA 中的氧化应激/抗氧化状态；然而，饮食成分对血清抗氧化能力的影响在这种疾病中尚未得到研究。本研究旨在评估 RA 患者和健康对照者的饮食质量与抗氧化状态之间的关系。对 82 名 RA 患者和 87 名健康对照者进行了营养评估，并测定了血清中的抗氧化状态（无蛋白和去蛋白后，分别为 TAS 和 DSAS）。RA 组的饮食能量低且不平衡。与对照组相比，RA 患者的 TAS 和 DSAS 明显较低。抗氧化状态与影响 RA 中抗氧化和抗炎防御的食物和营养素的供应呈显著相关；然而，在该组中，TAS 比 DSAS 对饮食更敏感。在健康受试者中，血清抗氧化剂的非蛋白池与饮食的关系更为密切。这些结果表明，需要监测 RA 患者的饮食质量，并且 TAS 测量在这种监测中是有用的。
