心肌纤维化的干预靶点：自噬。
An Intervention Target for Myocardial Fibrosis: Autophagy.
机构信息
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Department of Cardiovascular Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
出版信息
Biomed Res Int. 2018 Apr 2;2018:6215916. doi: 10.1155/2018/6215916. eCollection 2018.
Abstract
Myocardial fibrosis (MF) is the result of metabolic imbalance of collagen synthesis and metabolism, which is widespread in various cardiovascular diseases. Autophagy is a lysosomal degradation pathway which is highly conserved. In recent years, research on autophagy has been increasing and the researchers have also become cumulatively aware of the specified association between autophagy and MF. This review highlights the role of autophagy in MF and the potential effects through the administration of medicine.
摘要
心肌纤维化（MF）是胶原合成和代谢代谢失衡的结果，广泛存在于各种心血管疾病中。自噬是一种高度保守的溶酶体降解途径。近年来，自噬的研究不断增加，研究人员也逐渐认识到自噬与 MF 之间的特定关联。本文综述了自噬在 MF 中的作用及其通过药物干预的潜在影响。
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