[心血管系统中的自噬]

[Autophagy in the cardiovascular system].

作者信息

Kheloufi Marouane, Rautou Pierre-Emmanuel, Boulanger Chantal M

机构信息

Inserm, U970, Paris cardiovascular research center - PARCC, 56, rue Leblanc, 75015 Paris, France - Université Paris Descartes, Sorbonne Paris Cité, UMR-S 970, Paris, France - Université Denis Diderot-Paris 7, Sorbonne Paris Cité, 75018 Paris, France.

Inserm, U970, Paris cardiovascular research center - PARCC, 56, rue Leblanc, 75015 Paris, France - Université Paris Descartes, Sorbonne Paris Cité, UMR-S 970, Paris, France - Service d'hépatologie, DHU unity, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France.

出版信息

Med Sci (Paris). 2017 Mar;33(3):283-289. doi: 10.1051/medsci/20173303015. Epub 2017 Apr 3.

DOI:10.1051/medsci/20173303015

PMID:28367815

Abstract

Cardiovascular diseases are the leading cause of mortality worldwide. Studies regarding the role of autophagy in cardiac and vascular tissues have opened new therapeutic avenues to treat cardiovascular disorders. Altogether, these studies point out that autophagic activity needs to be maintained at an optimal level to preserve cardiovascular function. Reaching this goal constitutes a challenge for future efficient therapeutic strategies. The present review therefore highlights recent advances in the understanding of the role of autophagy in cardiovascular pathologies.

摘要

心血管疾病是全球范围内主要的死亡原因。关于自噬在心脏和血管组织中的作用的研究为治疗心血管疾病开辟了新的治疗途径。总之，这些研究指出，自噬活性需要维持在最佳水平以保持心血管功能。实现这一目标对未来有效的治疗策略构成了挑战。因此，本综述重点介绍了在理解自噬在心血管疾病中的作用方面的最新进展。