Brown R D, Rickard K A, Kronenberg H
Br J Haematol. 1985 Apr;59(4):617-26. doi: 10.1111/j.1365-2141.1985.tb07356.x.
Evidence of a defect in the negative feedback control of granulopoiesis in the myeloproliferative disorders is presented. Neutrophil release of lactoferrin, plasma lactoferrin concentration, the number of lactoferrin receptor sites on mononuclear cells and granulocyte-monocyte colony stimulating factor (GM-CSF) release from peripheral blood cells were determined in patients with myeloproliferative disorders and compared with normal individuals. There was a significantly (P less than 0.001) decreased release of lactoferrin from the neutrophils of patients with myeloproliferative disorders which could be responsible for a reduced suppression of GM-CSF release from mononuclear cells which in turn may be responsible for the increased myeloid proliferative activity in patients with myeloproliferative disorders.
本文提出了骨髓增殖性疾病中粒细胞生成负反馈控制存在缺陷的证据。测定了骨髓增殖性疾病患者中性粒细胞乳铁蛋白的释放、血浆乳铁蛋白浓度、单核细胞上乳铁蛋白受体位点的数量以及外周血细胞中粒细胞-单核细胞集落刺激因子（GM-CSF）的释放，并与正常个体进行了比较。骨髓增殖性疾病患者中性粒细胞乳铁蛋白的释放显著减少（P<0.001），这可能导致对单核细胞GM-CSF释放的抑制作用减弱，进而可能导致骨髓增殖性疾病患者的髓系增殖活性增加。
