在微小盘基网柄菌早期发育成熟过程中，环磷酸腺苷（cAMP）会诱导环磷酸鸟苷（cGMP）水平短暂升高。

cAMP induces a transient elevation of cGMP levels during early culmination of Dictyostelium minutum.

作者信息

Schaap P, Wang M

出版信息

Cell Differ. 1985 Feb;16(1):29-33. doi: 10.1016/0045-6039(85)90604-9.

Abstract

Oscillatory cAMP signals very likely organize the cell movement which leads to fruiting body construction in Dictyostelium minutum [Schaap, P., Konijn, T.M. and Van Haastert, P.J.M.: Proc. Natl. Acad. Sci. USA 81, 2122-2126 (1984)]. Stimulation with cAMP induces a transient elevation of cGMP in cells at the early culmination stage, which peaks at 12-18 s. A half maximal cGMP response is induced by 10(-7) M cAMP and saturation of the response is reached at 10(-5) M cAMP. No cGMP accumulation was induced by stimulation of vegetative or aggregative cells of D. minutum by cAMP. Since the transient increase of cGMP is most likely involved in the transduction of chemotactic signals, our results indicate that cAMP signals organize fruiting body formation by inducing chemotaxis inside the aggregate.

摘要

振荡的环磷酸腺苷（cAMP）信号很可能调控了微小盘基网柄菌中导致子实体形成的细胞运动[Schaap, P., Konijn, T.M.和Van Haastert, P.J.M.: 《美国国家科学院院刊》81, 2122 - 2126 (1984)]。在发育后期，用cAMP刺激会诱导细胞内环磷酸鸟苷（cGMP）短暂升高，在12 - 18秒时达到峰值。10⁻⁷ M的cAMP可诱导产生半数最大cGMP反应，而在10⁻⁵ M的cAMP时反应达到饱和。用cAMP刺激微小盘基网柄菌的营养细胞或聚集细胞不会诱导cGMP积累。由于cGMP的短暂增加很可能参与趋化信号的转导，我们的结果表明cAMP信号通过在聚集体内部诱导趋化作用来调控子实体的形成。