Analytical Chemistry Department, University of Valencia, 50(th) Dr. Moliner St., 46100, Burjassot, Spain.
Analytical Chemistry Department, University of Valencia, 50(th) Dr. Moliner St., 46100, Burjassot, Spain.
Anal Chim Acta. 2018 Oct 5;1026:37-50. doi: 10.1016/j.aca.2018.03.059. Epub 2018 Apr 18.
Ion mobility spectrometry (IMS) is a rapid and high sensitive technique widely used in security and forensic areas. However, a lack of selectivity is usually observed in the analysis of complex samples due to the scarce resolution of the technique. The literature concerning the use of conventional and novel smart materials in the pretreatment and preconcentration of samples previous to IMS determinations has been critically reviewed. The most relevant strategies to enhance selectivity and sensitivity of IMS determinations have been widely discussed, based in the use of smart materials, as immunosorbents, aptamers, molecularly imprinted polymers (MIPs), ionic liquids (ILs) and nanomaterial. The observed trend is focused on the development of IMS analytical methods in combination of selective sample treatments in order to achieve quick, reliable, sensitive, and selective methods for the analysis of complex samples such as biological fluids, food, or environmental samples.
离子迁移谱（IMS）是一种快速、高灵敏度的技术，广泛应用于安全和法医领域。然而，由于该技术分辨率较低，在分析复杂样品时通常观察到选择性不足。本文批判性地综述了关于在 IMS 测定前使用常规和新型智能材料对样品进行预处理和预浓缩的文献。广泛讨论了基于使用智能材料（如免疫吸附剂、适体、分子印迹聚合物（MIP）、离子液体（IL）和纳米材料）来提高 IMS 测定选择性和灵敏度的最相关策略。观察到的趋势集中在结合选择性样品处理开发 IMS 分析方法，以实现对生物体液、食品或环境样品等复杂样品的快速、可靠、敏感和选择性分析方法。
