Efficient synthesis of PMMA@CoNiFeO organic-inorganic hybrids containing hyamine 1622 - Physicochemical properties, cytotoxic assessment and antimicrobial activity.

The PMMA@CoNiFeO ferrite containing hybrid nanomaterials with hyamine were prepared using emulsion polymerization method. Structural and morphological properties were evaluated using XRD, FT-IR, SEM techniques. The TGA and DTA analysis were performed in order to study the thermal properties of hybrid materials in contrast to reference material. Magnetic properties were studied using Quantum Design PPMS (VSM option) in a constant external magnetic field equal (100 Oe and 1000 Oe) in the temperature range from 2 to 380 K. Both the pure CoNiFeOand the sample with 85% of PMMA exhibit superparamagnetic behavior whereas blocking temperatureT decreases with increase of PMMA content. The cytotoxicity assessment of PMMA@CoNiFeO with hyamine in J774.E murine macrophages and U2OS human osteosarcoma cell lines was performed. Additionally, sensitivity of bacteria Escherichia coli ATCC 8739 and Staphylococcus aureus ATCC 25923 to hybrid materials (with/without hyamine) was investigated using a of Kirby-Bauer disc method.