Maruyama S, Zhang G, Tamura Y, Yamakuni T, Takahashi Y
Eur J Pharmacol. 1985 Feb 5;108(3):309-13. doi: 10.1016/0014-2999(85)90455-8.
Spot 35 protein, applied iontophoretically, produced inhibition of spontaneous Purkinje cell activity in most cells and augmented the NE- or 5-HT-induced inhibition of spontaneous discharges whereas it hardly affected the inhibitory response of Purkinje cells to GABA, taurine, and beta-alanine, and the excitatory response to glutamate. It is suggested that spot 35 protein may be involved in normal physiological operation of the cerebellum through modulation of the NE or 5-HT system.
经离子电渗法施加的斑点35蛋白，在大多数细胞中抑制浦肯野细胞的自发活动，并增强去甲肾上腺素或5-羟色胺诱导的对自发放电的抑制作用，而它几乎不影响浦肯野细胞对γ-氨基丁酸、牛磺酸和β-丙氨酸的抑制反应以及对谷氨酸的兴奋反应。这表明斑点35蛋白可能通过调节去甲肾上腺素或5-羟色胺系统参与小脑的正常生理运作。
