钙调蛋白介导的G-肌动蛋白聚合反应
Polymerization of G-actin by caldesmon.
作者信息
Gałazkiewicz B, Mossakowska M, Osińska H, Dabrowska R
出版信息
FEBS Lett. 1985 May 6;184(1):144-9. doi: 10.1016/0014-5793(85)80671-2.
PMID:2985442
Abstract
Electron microscopy of negatively stained samples indicates that caldesmon induces polymerization of G-actin into filaments. Polymerization takes place in a very low ionic strength solution and is accompanied by an increase of intensity of fluorescence of G-actin labelled with N-(1-pyrenyl)iodoacetamide. The effect of caldesmon is abolished by calmodulin in the presence of Ca2+.
摘要
对经负染的样品进行电子显微镜观察表明，钙调蛋白可诱导G-肌动蛋白聚合成细丝。聚合反应在极低离子强度的溶液中发生，并伴随着用N-(1-芘基)碘乙酰胺标记的G-肌动蛋白荧光强度的增加。在Ca2+存在的情况下，钙调蛋白可消除钙调蛋白的作用。
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