伴有淋巴结和肺转移的皮肤基底细胞癌

Wahl Renate U, Cacchi Claudio, Rübben Albert

Department of Dermatology, Euregional Skin Cancer Center, University Hospital of the RWTH-Aachen, Aachen, Germany.

Department of Pathology, University Hospital of the RWTH-Aachen, Aachen, Germany.

Case Rep Oncol Med. 2018 Apr 24;2018:3485326. doi: 10.1155/2018/3485326. eCollection 2018.

Basal cell carcinoma (BCC) is the most common skin cancer. Metastatic BCC is an extraordinary rare finding observed in only 0.5% of all cases. Until the introduction of the small molecule hedgehog inhibitor vismodegib, patients with metastatic BCC were treated with chemotherapy, most frequently platinum-based with mixed responses to therapy. We present the case of a 55-year-old Caucasian man who suffered from BCC on his left arm with lymph node and pulmonary metastases. Sonic hedgehog blockade with vismodegib only induced a short remission, and the patient succumbed to the cancer.

基底细胞癌（BCC）是最常见的皮肤癌。转移性基底细胞癌极为罕见，仅在所有病例的0.5%中出现。在小分子刺猬信号通路抑制剂维莫德吉问世之前，转移性基底细胞癌患者接受化疗，最常用的是铂类化疗，治疗反应不一。我们报告一例55岁的白种男性患者，其左臂患有基底细胞癌并伴有淋巴结和肺转移。使用维莫德吉阻断刺猬信号通路仅诱导了短暂缓解，患者最终死于癌症。