Department of Dermatology, Venereology, and Allergology, Wroclaw Medical University, Wrocław, Poland.
Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.
Anal Cell Pathol (Amst). 2018 May 2;2018:1956403. doi: 10.1155/2018/1956403. eCollection 2018.
Atopic dermatitis (AD) is a condition with a complex and not fully understood etiology. In patients with AD, acute skin lesions are colonized by a greater number of () bacteria than chronic lesions, clinically unchanged atopic skin, or the skin of healthy people. Mechanisms promoting skin colonization by include complex interactions among several factors. Apart from increased adhesion of in atopic skin, defects of the innate immune response resulting in the lack of restriction of the growth of microorganisms also contribute to susceptibility to colonization by and infection with . A deficiency in the endogenous antimicrobial peptides may be partly responsible for the susceptibility to colonization by and skin infection with in patients with AD. Majority of isolated stains are able to produce exotoxins, which act as superantigens. Moreover, anti--specific IgE was identified and measured in patients with AD, revealing that its level corresponds to the severity of the disease. This review of the literature attempts to identify factors that are involved in the pathogenesis of AD-related skin colonization. In the light of presented mechanisms, a reduction of colonization may become both causative and symptomatic treatment in AD.
特应性皮炎（AD）是一种病因复杂且尚未完全阐明的疾病。与慢性皮损、临床无变化的特应性皮肤或健康人的皮肤相比，AD 患者的急性皮损中定植有更多数量的（）细菌。促进皮肤定植的机制包括几个因素之间的复杂相互作用。除了（）在特应性皮肤中的黏附增加外，固有免疫反应的缺陷导致对微生物生长的限制缺失，也有助于（）定植和感染。内源性抗菌肽的缺乏可能部分导致 AD 患者对（）定植和皮肤感染的易感性。分离出的大多数（）菌株能够产生外毒素，这些毒素作为超抗原发挥作用。此外，在 AD 患者中鉴定并测量了针对的特异性 IgE，结果表明其水平与疾病的严重程度相对应。对文献的综述试图确定与 AD 相关（）皮肤定植相关的发病机制中的因素。鉴于所提出的机制，减少定植可能成为 AD 的病因和症状治疗方法。
