油可保护雄性大鼠免受柠檬黄毒性的影响。

oil protects against tartrazine toxicity in male rats.

作者信息

Al-Seeni Madeha N, El Rabey Haddad A, Al-Hamed Amani Mohammed, Zamazami Mazin A

机构信息

Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.

出版信息

Toxicol Rep. 2017 Dec 28;5:146-155. doi: 10.1016/j.toxrep.2017.12.022. eCollection 2018.

This study aimed to evaluate the protective role of oil against the adverse effects of tartrazine on male rats. 18 albino rats were divided randomly into four groups (n = 6). The first (G1) is the negative control, the second group (G2) is the positive control received 10 mg/kg b.w. tartrazine in the diet and the third (G3) received the same dose of tartrazine as in G2 and co-treated with oil for 8 weeks. Tartrazine decreased total protein, antioxidants and high density lipoproteins, whereas increased liver enzyme, kidney function parameters, total cholesterol, triglycerides, low density lipoproteins and lipid peroxidation in the positive control group. In addition, it caused pathological changes in the tissues of liver, kidney, testes and stomach. Treating tartrazine supplemented rats of G3 with oil for 8 weeks significantly improved all biochemical parameters and restored the tissues of kidney, stomach, testes and liver to normal. It could be concluded that oil succeeded in protecting male rats against the adverse conditions resulted from tartrazine administration.

本研究旨在评估[某种油]对柠檬黄对雄性大鼠不良影响的保护作用。将18只白化大鼠随机分为四组（n = 6）。第一组（G1）为阴性对照组，第二组（G2）为阳性对照组，在饮食中接受10 mg/kg体重的柠檬黄，第三组（G3）接受与G2相同剂量的柠檬黄，并与[某种油]共同处理8周。在阳性对照组中，柠檬黄降低了总蛋白、抗氧化剂和高密度脂蛋白，而增加了肝酶、肾功能参数、总胆固醇、甘油三酯、低密度脂蛋白和脂质过氧化。此外，它还导致肝脏、肾脏、睾丸和胃组织发生病理变化。用[某种油]对G3组补充柠檬黄的大鼠进行8周治疗，显著改善了所有生化参数，并使肾脏、胃、睾丸和肝脏组织恢复正常。可以得出结论，[某种油]成功地保护了雄性大鼠免受柠檬黄给药所导致的不良状况。