Opt Lett. 2018 Jun 1;43(11):2591-2594. doi: 10.1364/OL.43.002591.
X-ray fluorescence (XRF) tomography is an emerging imaging technology with the potential for high spatial resolution molecular imaging. One of the key limitations is the background noise due to Compton scattering since it degrades the signal and limits the sensitivity. In this Letter, we present a linear focused anti-scatter grid that reduces the Compton scattering background. An anti-scatter grid was manufactured and evaluated both experimentally and theoretically with Monte Carlo simulations. The measurements showed a 31% increase in signal-to-background ratio, and simulations of an improved grid showed that this can easily be extended up to >75%. Simulated tomographies using the improved grid show a large improvement in reconstruction quality. The anti-scatter grid will be important for in vivo XRF tomography since the background reduction allows for faster scan times, lower doses, and lower nanoparticle concentrations.
X 射线荧光（XRF）断层扫描是一种新兴的成像技术，具有实现高空间分辨率分子成像的潜力。其中一个关键的限制因素是由于康普顿散射引起的背景噪声，因为它会降低信号并限制灵敏度。在本信中，我们提出了一种线性聚焦反散射栅，可减少康普顿散射背景。制造了反散射栅，并通过蒙特卡罗模拟进行了实验和理论评估。测量结果显示信号与背景的比值提高了 31%，对改进型栅格的模拟表明，这很容易扩展到>75%。使用改进型栅格进行的模拟断层扫描显示出重建质量的大幅提高。反散射栅对于体内 XRF 断层扫描非常重要，因为背景减少允许更快的扫描时间、更低的剂量和更低的纳米颗粒浓度。
