Yue Qing-xi, Yu Hong, He Ting, Yu Hai-qing
Yao Xue Xue Bao. 2016 Feb;51(2):208-14.
The formation and metastasis of tumor cells are closely related to the gene regulation. It is critical to elucidate the molecular mechanism of a compound using in cancer therapy. In this article, we reviewed the anti-cancer molecular mechanism of arsenic trioxide and artemisinin. Its anti-cancer function mainly includes: regulation of cell cycle regulatory proteins to inhibit tumor cell proliferation, cell apoptosis signal transduction pathway to promote apoptosis in tumor cells, immortalization associated genes to reduce the life of tumor cells, angiogenesis/invasion/metastasis gene to block the spread of tumor cells, promoter methylation and protein ubiquitination gene to enhance anti-oncogene expression and ubiquitin- mediated protein degradation, micro RNA to inhibit proliferation or induce apoptosis in tumor cells, DNA synthesis and repair of DNA damage and repair gene to decrease the DNA synthesis of tumor cells, signal transduction pathways of cell proliferation/apoptosis and invasion/metastasis etc., the expression of hormone receptors and so on. We indicated the problems existing in current studies and also prospected the future of using the compound to fight cancer.
肿瘤细胞的形成和转移与基因调控密切相关。阐明一种用于癌症治疗的化合物的分子机制至关重要。在本文中，我们综述了三氧化二砷和青蒿素的抗癌分子机制。其抗癌功能主要包括：调节细胞周期调节蛋白以抑制肿瘤细胞增殖、细胞凋亡信号转导通路以促进肿瘤细胞凋亡、永生化相关基因以缩短肿瘤细胞寿命、血管生成/侵袭/转移基因以阻止肿瘤细胞扩散、启动子甲基化和蛋白质泛素化基因以增强抗癌基因表达和泛素介导的蛋白质降解、微小RNA以抑制肿瘤细胞增殖或诱导其凋亡、DNA合成以及DNA损伤修复基因以减少肿瘤细胞的DNA合成、细胞增殖/凋亡以及侵袭/转移等信号转导通路、激素受体的表达等。我们指出了当前研究中存在的问题，并对使用该化合物抗癌的未来进行了展望。
