Department of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, PR China.
First Department of General Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, PR China.
Psychiatry Res. 2018 Aug;266:97-102. doi: 10.1016/j.psychres.2018.04.059. Epub 2018 May 6.
There is evidence that bipolar disorder (BD) patients with an unhealthy lifestyle have a worse course of illness. This study was designed to examine the extent to which lifestyle could influence the severity of clinical symptoms associated with BD. A total of 113 BD patients were recruited in this study. The lifestyle information including data on dietary patterns, physical activity, and sleep quality were collected using a self-rated questionnaire. The results showed that the consumption of whole grain, seafood, and dairy products were significantly negatively correlated with the 17-item Hamilton Rating Scale for Depression (HAMD-17) total score. The consumption of sugar, soft drinks, and alcohol as well as being a current smoker were positively correlated with the severity of clinical symptoms. Multiple linear regression and binary logistic regression analyses demonstrated an independent negative correlation between both whole grain and dairy product consumption with the HAMD-17 score. The results from the current study suggested that lifestyle factors, especially dietary patterns, might be associated with clinical symptoms of BD. The association between the consumption of specific foods and severity of depressive symptoms may offer some useful information and further understanding of the role of lifestyle factors in the development of BD.
有证据表明，生活方式不健康的双相情感障碍（BD）患者病情更糟。本研究旨在探讨生活方式在多大程度上可能影响与 BD 相关的临床症状的严重程度。共有 113 名 BD 患者参与了这项研究。使用自我评估问卷收集了生活方式信息，包括饮食模式、身体活动和睡眠质量的数据。结果表明，全谷物、海鲜和奶制品的摄入量与 17 项汉密尔顿抑郁量表（HAMD-17）总分呈显著负相关。糖、软饮料和酒精的摄入以及当前吸烟与临床症状的严重程度呈正相关。多元线性回归和二元逻辑回归分析表明，全谷物和奶制品的摄入与 HAMD-17 评分之间存在独立的负相关。本研究的结果表明，生活方式因素，特别是饮食模式，可能与 BD 的临床症状有关。特定食物的摄入与抑郁症状严重程度之间的关联可能提供一些有用的信息，并进一步了解生活方式因素在 BD 发展中的作用。
