Child and adolescent psychiatry unit - Grenoble University Hospital, Univ. Grenoble Alpes, France.
LIP/PC2S, University of Grenoble Alpes, Grenoble 38000, France.
Psychiatry Res. 2018 Aug;266:212-217. doi: 10.1016/j.psychres.2018.05.024. Epub 2018 May 17.
Anorexia nervosa (AN) is a serious psychiatric disorder associated with the highest mortality rate. Body dissatisfaction (BD) is now considered as an important risk factor for AN onset and relapse. Recent results lead to the hypothesis according to which AN and drive for thinness (DT) are related to body dissatisfaction. The primary aim of this current study was to identify whether DT mediated the relationship between BD and AN symptoms several years after hospitalization. As a secondary aim, self-reported Body Shape Questionnaire, Eating Attitude Test, Eating Disorder Inventory and Beck Depression Inventory scores were compared between the 48 women with a history of severe AN and 73 matched controls. A mediation analysis didn't show evidence of a direct effect of BD on eating disorder symptomatology after controlling for DT suggesting a full mediation of DT on the association between BD and eating disorders symptomatology. Results also showed that patients with a bad outcome had a higher score of DT than controls, which was not the case of patients with a good outcome. These findings highlight the potential importance of DT and the usefulness of targeting this dimension in therapeutic interventions for AN patients if further research confirm these results.
神经性厌食症（AN）是一种严重的精神疾病，死亡率最高。身体不满（BD）现在被认为是 AN 发病和复发的一个重要危险因素。最近的结果导致了这样一种假设，即 AN 和对瘦的渴望（DT）与身体不满有关。本研究的主要目的是确定在住院几年后，DT 是否在 BD 和 AN 症状之间的关系中起中介作用。作为次要目的，我们比较了 48 名有严重 AN 病史的女性和 73 名匹配对照者的自我报告的身体形状问卷、饮食态度测试、饮食障碍量表和贝克抑郁量表评分。中介分析显示，在控制 DT 后，BD 对饮食障碍症状没有直接影响，这表明 DT 完全中介了 BD 与饮食障碍症状之间的关联。结果还表明，预后不良的患者的 DT 评分高于对照组，而预后良好的患者则不然。这些发现强调了 DT 的重要性，如果进一步的研究证实了这些结果，那么在治疗 AN 患者时，针对这一维度可能具有重要意义。
