急性口服大麻二酚酸甲酯可减轻两种抑郁症基因动物模型中的抑郁样行为。
Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression.
作者信息
Hen-Shoval D, Amar S, Shbiro L, Smoum R, Haj Christeene G, Mechoulam R, Zalsman G, Weller A, Shoval G
机构信息
Psychology Department, Bar-Ilan University, Ramat Gan, Israel; Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
出版信息
Behav Brain Res. 2018 Oct 1;351:1-3. doi: 10.1016/j.bbr.2018.05.027. Epub 2018 May 31.
BACKGROUND AND PURPOSE
Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression.
EXPERIMENTAL APPROACH
Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar-Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats.
KEY RESULTS
1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05).
CONCLUSION AND IMPLICATIONS
This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.
背景与目的
大麻二酚酸甲酯（HU - 580）最近被证明可减轻大鼠应激诱导的焦虑样行为。本研究的目的是在两种不同的大鼠抑郁模型中检测HU - 580的抗抑郁作用。
实验方法
使用强迫游泳试验（FST），我们评估了HU - 580对43只成年雄性Wistar - Kyoto（WKY）大鼠和23只成年雄性弗林德斯敏感系（FSL）大鼠的作用。
主要结果
与给予赋形剂的对照组相比，1 mg/kg的HU - 580可减少WKY大鼠的不动时间并增加其游泳时间（p < 0.05）。该剂量在FSL大鼠中也产生了类似的效果（p < 0.05）。
结论与意义
这是关于HU - 580抗抑郁疗效的首次报道。这些发现扩展了非常有限的现有结果，表明HU - 580是一种有效的抗焦虑剂。结合其化学稳定性，HU - 580有望成为未来抗抑郁药物的候选者。
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