Hen-Shoval D, Amar S, Shbiro L, Smoum R, Haj Christeene G, Mechoulam R, Zalsman G, Weller A, Shoval G
Psychology Department, Bar-Ilan University, Ramat Gan, Israel; Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Behav Brain Res. 2018 Oct 1;351:1-3. doi: 10.1016/j.bbr.2018.05.027. Epub 2018 May 31.
Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression.
Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar-Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats.
1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05).
This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.
大麻二酚酸甲酯（HU - 580）最近被证明可减轻大鼠应激诱导的焦虑样行为。本研究的目的是在两种不同的大鼠抑郁模型中检测HU - 580的抗抑郁作用。
使用强迫游泳试验（FST），我们评估了HU - 580对43只成年雄性Wistar - Kyoto（WKY）大鼠和23只成年雄性弗林德斯敏感系（FSL）大鼠的作用。
与给予赋形剂的对照组相比，1 mg/kg的HU - 580可减少WKY大鼠的不动时间并增加其游泳时间（p < 0.05）。该剂量在FSL大鼠中也产生了类似的效果（p < 0.05）。
这是关于HU - 580抗抑郁疗效的首次报道。这些发现扩展了非常有限的现有结果，表明HU - 580是一种有效的抗焦虑剂。结合其化学稳定性，HU - 580有望成为未来抗抑郁药物的候选者。
