Molecular Imaging and Neuropathology Division, Department of Psychiatry, Columbia University Medical Center (CUMC) and New York State Psychiatric Institute, New York, NY, USA.
Molecular Imaging and Neuropathology Division, Department of Psychiatry, Columbia University Medical Center (CUMC) and New York State Psychiatric Institute, New York, NY, USA.
J Affect Disord. 2018 Oct 1;238:62-68. doi: 10.1016/j.jad.2018.05.022. Epub 2018 May 17.
Oxytocin may moderate prosocial behaviors, but has also been implicated in negative mental health outcomes. A single-nucleotide polymorphism (SNP) of the oxytocin receptor gene (OXTR), rs53576, and a SNP of the CD38 gene, which regulates oxytocin secretion, rs3796863, have been associated with depression and suicidal ideation.
We conducted an exploratory study investigating the relationship of these two SNPs to history of suicide attempt. Secondary analyses explored relationships of genotype with sex, diagnosis, history of abuse, depression, suicidal ideation, and attachment and personality traits. Subjects were depressed adults with DSM-IV major depressive disorder (MDD; n = 161) or bipolar disorder (BD; n = 75).
The A allele of rs53576 was associated with suicide attempt history. A differential effect of rs3796863 genotype on suicide attempt risk was found by diagnosis. In the BD sample, CC and AC genotypes were associated with higher odds of suicide attempt compared to AA, while in the MDD sample, AC subjects were more likely than CC subjects to have made an attempt.
Our assessment of social sensitivity was limited to measures of attachment style and abuse history and did not differentiate between types of abuse. Plasma oxytocin was not measured.
These findings add to evidence for the involvement of oxytocin in suicide attempts and identify a potential biomarker for differentiating depressed attempters from non-attempters.
催产素可能调节亲社会行为，但也与负面心理健康结果有关。催产素受体基因（OXTR）的一个单核苷酸多态性（SNP）rs53576 和调节催产素分泌的 CD38 基因的一个 SNP rs3796863 与抑郁症和自杀意念有关。
我们进行了一项探索性研究，调查了这两个 SNP 与自杀未遂史的关系。二次分析探讨了基因型与性别、诊断、滥用史、抑郁、自杀意念以及依恋和人格特质的关系。研究对象为 DSM-IV 重性抑郁障碍（MDD；n=161）或双相障碍（BD；n=75）的抑郁成年患者。
rs53576 的 A 等位基因与自杀未遂史有关。rs3796863 基因型对自杀未遂风险的影响因诊断而异。在 BD 样本中，CC 和 AC 基因型与自杀未遂的几率较高，而在 MDD 样本中，AC 受试者比 CC 受试者更有可能尝试自杀。
我们对社会敏感性的评估仅限于依恋风格和滥用史的测量，并未区分滥用的类型。未测量血浆催产素。
这些发现增加了催产素参与自杀未遂的证据，并确定了区分抑郁未遂者和非未遂者的潜在生物标志物。
