• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

18-甘草次酸对真菌蛋白酶诱导的气道炎症反应的影响。

Effects of 18-Glycyrrhetinic Acid on Fungal Protease-Induced Airway Inflammatory Responses.

机构信息

Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine (KIOM), Daejeon 34054, Republic of Korea.

出版信息

Mediators Inflamm. 2018 May 15;2018:6461032. doi: 10.1155/2018/6461032. eCollection 2018.

DOI:10.1155/2018/6461032
PMID:29861658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5976916/
Abstract

Airway epithelial cells secrete diverse inflammatory mediators in response to various stimuli. Thus, early regulation of immune responses in the airway epithelium is likely critical for the control of chronic inflammatory diseases. The purpose of the present study was to evaluate the effects of 18-glycyrrhetinic acid (GA) on inflammatory responses generated in response to a fungal protease allergen that induces epithelial damage. To understand the underlying mechanisms, we also investigated the inhibitory effects of GA on the production of mitochondrial reactive oxygen species (ROS) in the human bronchial epithelial cell line BEAS2B. In this study, GA treatment reduced cytokine production and the human neutrophil cell line HL60 migration through decreased mitochondrial ROS production. In addition, GA significantly reduced inflammatory cell infiltration and cytokine levels in the bronchoalveolar lavage (BAL) fluid of fungal allergen-administered mice. Inhibitory effects of GA are dependent on the mitochondrial ROS/MAPK axis. Moreover, the effect of GA on the regulation of mitochondrial ROS depends on the expression of uncoupling protein-2 (UCP-2). Taken together, GA might represent a potential therapeutic agent for blocking inflammatory responses in airways.

摘要

气道上皮细胞在受到各种刺激时会分泌多种炎症介质。因此，早期调节气道上皮的免疫反应可能对控制慢性炎症性疾病至关重要。本研究旨在评估 18-甘草次酸 (GA) 对诱导上皮损伤的真菌蛋白酶变应原引起的炎症反应的影响。为了了解潜在的机制，我们还研究了 GA 对人支气管上皮细胞系 BEAS2B 中线粒体活性氧 (ROS) 产生的抑制作用。在这项研究中，GA 处理通过减少线粒体 ROS 的产生，减少细胞因子的产生和人中性粒细胞 HL60 的迁移。此外，GA 还显著减少了真菌变应原给药小鼠支气管肺泡灌洗液 (BAL) 中的炎症细胞浸润和细胞因子水平。GA 的抑制作用依赖于线粒体 ROS/MAPK 轴。此外，GA 对线粒体 ROS 调节的作用取决于解偶联蛋白-2 (UCP-2) 的表达。总之，GA 可能代表一种潜在的治疗剂，可阻断气道中的炎症反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/81eb78a08a67/MI2018-6461032.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/6976edacbacd/MI2018-6461032.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/ed28e7631305/MI2018-6461032.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/3aac532950b1/MI2018-6461032.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/1e1b59f0a182/MI2018-6461032.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/6e1aed76d965/MI2018-6461032.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/3b9aea95f785/MI2018-6461032.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/81eb78a08a67/MI2018-6461032.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/6976edacbacd/MI2018-6461032.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/ed28e7631305/MI2018-6461032.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/3aac532950b1/MI2018-6461032.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/1e1b59f0a182/MI2018-6461032.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/6e1aed76d965/MI2018-6461032.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/3b9aea95f785/MI2018-6461032.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3a/5976916/81eb78a08a67/MI2018-6461032.007.jpg

相似文献

1
Effects of 18-Glycyrrhetinic Acid on Fungal Protease-Induced Airway Inflammatory Responses.18-甘草次酸对真菌蛋白酶诱导的气道炎症反应的影响。
Mediators Inflamm. 2018 May 15;2018:6461032. doi: 10.1155/2018/6461032. eCollection 2018.
2
18β-Glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways.18β-甘草次酸通过 NADPH 氧化酶/ROS/p38MAPK 和 NF-κB 途径减轻辐射诱导的皮肤损伤。
Environ Toxicol Pharmacol. 2018 Jun;60:82-90. doi: 10.1016/j.etap.2018.04.012. Epub 2018 Apr 13.
3
18β-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model.18β-甘草次酸是甘草的主要生物活性成分，在哮喘小鼠模型中，它通过调节Th2细胞因子、GATA-3、STAT6和Foxp3转录因子来减轻气道炎症。
Environ Toxicol Pharmacol. 2017 Jun;52:99-113. doi: 10.1016/j.etap.2017.03.011. Epub 2017 Mar 20.
4
18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway.18β-甘草次酸通过ROS/MAPKs介导的途径诱导垂体腺瘤细胞凋亡。
J Neurooncol. 2014 Jan;116(2):221-30. doi: 10.1007/s11060-013-1292-2. Epub 2013 Oct 27.
5
18β-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-α/ERK pathway.18β-甘草次酸通过ROS/PKC-α/ERK途径抑制人胃癌细胞的迁移和侵袭。
J Nat Med. 2018 Jan;72(1):252-259. doi: 10.1007/s11418-017-1145-y. Epub 2017 Nov 2.
6
TGF-β/SMAD4 mediated UCP2 downregulation contributes to Aspergillus protease-induced inflammation in primary bronchial epithelial cells.TGF-β/SMAD4 介导的 UCP2 下调导致曲霉菌蛋白酶诱导的原代支气管上皮细胞炎症。
Redox Biol. 2018 Sep;18:104-113. doi: 10.1016/j.redox.2018.06.011. Epub 2018 Jul 5.
7
Novel findings of 18β-glycyrrhetinic acid on sRAGE secretion through inhibition of transient receptor potential canonical channels in high-glucose environment.18β-甘草次酸通过抑制高糖环境中的瞬时受体电位经典通道促进 sRAGE 分泌的新发现。
Biofactors. 2019 Jul;45(4):607-615. doi: 10.1002/biof.1517. Epub 2019 May 23.
8
Mitochondrial reactive oxygen species regulate fungal protease-induced inflammatory responses.线粒体活性氧调节真菌蛋白酶诱导的炎症反应。
Toxicology. 2017 Mar 1;378:86-94. doi: 10.1016/j.tox.2017.01.008. Epub 2017 Jan 10.
9
Chemopreventive effect of 18β-glycyrrhetinic acid via modulation of inflammatory markers and induction of apoptosis in human hepatoma cell line (HepG2).18β-甘草次酸通过调节炎症标志物和诱导人肝癌细胞系（HepG2）凋亡发挥化学预防作用。
Mol Cell Biochem. 2016 May;416(1-2):169-77. doi: 10.1007/s11010-016-2705-2. Epub 2016 Apr 26.
10
18beta-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity.18β-甘草次酸诱导SiHa细胞发生凋亡性细胞死亡，并对抗生素抗癌药物毒性表现出协同作用。
Life Sci. 2008 Sep 26;83(13-14):481-9. doi: 10.1016/j.lfs.2008.07.014. Epub 2008 Aug 5.

引用本文的文献

1
Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential.18β-甘草次酸的药理学特性：一种具有治疗潜力的五环三萜类化合物
Plants (Basel). 2023 Mar 1;12(5):1086. doi: 10.3390/plants12051086.
2
Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2.甘草次酸通过靶向丝氨酸羟甲基转移酶2（SHMT2）来限制线粒体能量代谢。
iScience. 2022 May 4;25(5):104349. doi: 10.1016/j.isci.2022.104349. eCollection 2022 May 20.
3
Toxicity of : Subacute Toxicity Assessment and Metabolomic Identification of Relevant Biomarkers.

本文引用的文献

1
Mitochondrial reactive oxygen species regulate fungal protease-induced inflammatory responses.线粒体活性氧调节真菌蛋白酶诱导的炎症反应。
Toxicology. 2017 Mar 1;378:86-94. doi: 10.1016/j.tox.2017.01.008. Epub 2017 Jan 10.
2
Enhanced Th2 cell differentiation and function in the absence of Nox2.在缺乏 Nox2 的情况下增强 Th2 细胞的分化和功能。
Allergy. 2017 Feb;72(2):252-265. doi: 10.1111/all.12944. Epub 2016 Jul 6.
3
Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease.
的毒性：亚急性毒性评估及相关生物标志物的代谢组学鉴定
Front Pharmacol. 2022 Feb 28;13:803855. doi: 10.3389/fphar.2022.803855. eCollection 2022.
4
Attenuates Allergic Rhinitis-Induced Inflammation by Inhibiting Periostin Production.通过抑制骨膜蛋白的产生减轻变应性鼻炎诱导的炎症。
Pharmaceuticals (Basel). 2021 Sep 28;14(10):986. doi: 10.3390/ph14100986.
5
Solid-State Fermentation of to Optimize Extraction Process of Isoliquiritigenin from .甘草固态发酵以优化异甘草素提取工艺。 （你提供的原文内容不完整，推测是这样一个意思，完整准确的翻译需结合更完整的原文。）
Evid Based Complement Alternat Med. 2020 Nov 28;2020:8927858. doi: 10.1155/2020/8927858. eCollection 2020.
6
Novel 3'-Substituted-1',2',4'-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their -Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo.新型 18βH-甘草次酸 3'-取代-1',2',4'-恶二唑衍生物及其酰化酰胺肟：体外和体内抗肿瘤和抗炎活性的评价。
Int J Mol Sci. 2020 May 15;21(10):3511. doi: 10.3390/ijms21103511.
7
Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury.甘草衍生 18β-甘草次酸对肝损伤保护作用的研究进展。
Acta Pharmacol Sin. 2021 Jan;42(1):18-26. doi: 10.1038/s41401-020-0383-9. Epub 2020 Mar 6.
氧化应激诱导的线粒体功能障碍在慢性阻塞性肺疾病患者中驱动炎症和气道平滑肌重塑。
J Allergy Clin Immunol. 2015 Sep;136(3):769-80. doi: 10.1016/j.jaci.2015.01.046. Epub 2015 Mar 29.
4
Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways.线粒体活性氧通过调节丝裂原活化蛋白激酶（MAPK）和核因子κB（NF-κB）信号通路来调控小胶质细胞中脂多糖（LPS）诱导的促炎反应。
Neurosci Lett. 2015 Jan 1;584:191-6. doi: 10.1016/j.neulet.2014.10.016. Epub 2014 Oct 22.
5
Chemokines induced in human respiratory epithelial cells by IL-1 family of cytokines.
Folia Biol (Praha). 2014;60(4):180-6. doi: 10.14712/fb2014060040180.
6
ROS function in redox signaling and oxidative stress.ROS在氧化还原信号传导和氧化应激中发挥作用。
Curr Biol. 2014 May 19;24(10):R453-62. doi: 10.1016/j.cub.2014.03.034.
7
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases.氧化应激：胃肠道黏膜疾病发病机制中的一个重要因素。
Physiol Rev. 2014 Apr;94(2):329-54. doi: 10.1152/physrev.00040.2012.
8
CCL2 shapes macrophage polarization by GM-CSF and M-CSF: identification of CCL2/CCR2-dependent gene expression profile.CCL2 通过 GM-CSF 和 M-CSF 塑造巨噬细胞极化：鉴定 CCL2/CCR2 依赖性基因表达谱。
J Immunol. 2014 Apr 15;192(8):3858-67. doi: 10.4049/jimmunol.1302821. Epub 2014 Mar 17.
9
Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers.靶向线粒体活性氧作为炎症性疾病和癌症的新型治疗方法。
J Hematol Oncol. 2013 Feb 25;6:19. doi: 10.1186/1756-8722-6-19.
10
The airway epithelium in asthma.哮喘中的气道上皮。
Nat Med. 2012 May 4;18(5):684-92. doi: 10.1038/nm.2737.