de Godoy Jose Maria Pereira, Pereira de Godoy Henrique Jose, Gracino de Marqui Thatiany, Spessoto Luis Cesar, Godoy Maria de Fatima Guerreiro
Cardiology and Cardiovascular Surgery Department, The Medicine School in São José do Rio Preto (FAMERP), CNPq (National Council for Research and Development), São José do Rio Preto, SP, Brazil.
Universidade Federal do Mato Grosso Cuiabá, MT and Researcher Group of the Clínica Godoy, São José do Rio Preto, SP, Brazil.
ScientificWorldJournal. 2018 May 10;2018:6537253. doi: 10.1155/2018/6537253. eCollection 2018.
Lymphedema is a clinical condition resulting from the accumulation of macromolecules in the interstitial space with a consequent buildup of fluids.
The objective of this study was to compare the therapeutic response to treatment that mobilizes fluids between primary and secondary lymphedemas.
Thirty-three patients with severe leg lymphedema who underwent intensive treatment for five consecutive days in 2013 and 2014 at the Clínica Godoy were evaluated in a prospective clinical trial. Diagnosis was based on the patient's history and physical examination. Treatment consisted of eight hours/day of Mechanical Lymphatic Therapy using an electromechanical device (RAGodoy®) that performs plantar flexion and extension associated with 15 minutes of Cervical Lymphatic Therapy, a technique developed by Godoy and Godoy that involves stimulation in the cervical region and a grosgrain compression stocking alternated with elastic bandages. The unpaired -test and Fisher's exact test were used for statistical analysis with an alpha error of 5% ( value < 0.05) being considering acceptable. Secondary lymphedema was more prevalent in women (Fisher exact test value < 0.01).
The age of patients with secondary lymphedema was greater than those with primary lymphedema (unpaired -test: value < 0.03). The mean volume losses were 64.62% and 48.35% for the patients with secondary and primary lymphedema, respectively ( value < 0.03).
Women are more prevalent and older in the secondary lymphedema group. Volumetric reductions below the knee are faster with intensive treatment for secondary rather than for primary lymphedema.
淋巴水肿是一种临床病症,由大分子在间质间隙中积聚并随之导致液体蓄积引起。
本研究的目的是比较原发性和继发性淋巴水肿对促进液体流动治疗的反应。
2013年和2014年在戈多伊诊所对33例严重腿部淋巴水肿患者进行了前瞻性临床试验评估,这些患者连续五天接受强化治疗。诊断基于患者病史和体格检查。治疗包括每天八小时使用机电设备(RAGodoy®)进行机械淋巴治疗,该设备进行与15分钟颈部淋巴治疗相关的跖屈和背伸,颈部淋巴治疗是戈多伊和戈多伊开发的一种技术,涉及颈部区域刺激以及交替使用粗粒纹弹力袜和弹性绷带。采用非配对t检验和Fisher精确检验进行统计分析,α错误率为5%(P值<0.05)被认为是可接受的。继发性淋巴水肿在女性中更为普遍(Fisher精确检验P值<0.01)。
继发性淋巴水肿患者的年龄大于原发性淋巴水肿患者(非配对t检验:P值<0.03)。继发性和原发性淋巴水肿患者的平均体积减少分别为64.62%和48.35%(P值<0.03)。
继发性淋巴水肿组中女性更为普遍且年龄更大。对继发性而非原发性淋巴水肿进行强化治疗时,膝部以下的体积减少更快。