向机体警示组织损伤：警报素和损伤相关分子模式在皮肤伤口愈合中的作用
Alerting the body to tissue injury: The role of alarmins and DAMPs in cutaneous wound healing.
作者信息
Wilgus Traci A
机构信息
The Ohio State University, Department of Pathology.
出版信息
Curr Pathobiol Rep. 2018 Mar;6(1):55-60. doi: 10.1007/s40139-018-0162-1. Epub 2018 Jan 20.
Abstract
PURPOSE OF REVIEW
Tissue injury stimulates an inflammatory response that is mediated in part by alarmins. Alarmins are a group of endogenous molecules that trigger inflammation in response to damage. This class of molecules is becoming increasingly recognized for their ability to influence wound healing. This article will provide an overview of alarmins and outline the latest findings on these mediators in cutaneous wound healing.
RECENT FINDINGS
In addition to stimulating inflammatory cells, recent evidence suggests that alarmins can act on other cells in the skin to affect wound closure and the extent of scar tissue production. This review will focus on HMGB-1 and IL-33, two alarmins that have received recent attention in the wound healing field.
SUMMARY
Because a properly regulated inflammatory response is critical for optimal healing, further research must be done to fully understand the role of alarmins in the wound repair process.
摘要
综述目的
组织损伤会引发炎症反应，其中一部分由警报素介导。警报素是一类内源性分子，可在损伤时触发炎症。这类分子因其影响伤口愈合的能力而越来越受到认可。本文将概述警报素，并概述这些介质在皮肤伤口愈合中的最新研究结果。
最新发现
除了刺激炎症细胞外，最近的证据表明警报素可以作用于皮肤中的其他细胞，以影响伤口闭合和瘢痕组织形成的程度。本综述将重点关注HMGB-1和IL-33这两种最近在伤口愈合领域受到关注的警报素。
总结
由于适当调节的炎症反应对于最佳愈合至关重要，因此必须进行进一步研究以充分了解警报素在伤口修复过程中的作用。
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