嘌呤能P2X受体与外周动脉疾病中增强的运动升压反射
Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease.
作者信息
Li Jianhua, Cui Jian
机构信息
Heart & Vascular Institute, The Penn State University College of Medicine, Hershey, PA 17033.
出版信息
Intern Med Rev (Wash D C). 2016 Nov;2(10). doi: 10.18103/imr.v2i10.259.
Abstract
Arterial blood pressure (BP) and vasoconstriction regulated by sympathetic nerve activity (SNA) are heightened during exercise in patients with peripheral artery disease (PAD). The exercise pressor reflex is considered as a neural mechanism responsible for the exaggerated autonomic responses to exercise in PAD. A series of studies have employed a rat model of PAD to examine signal pathways at receptor and cellular levels by which the exercise pressor reflex is amplified. This review will summarize results obtained from recent human and animal studies with respect to contribution of muscle afferents to augmented SNA and BP responses in PAD. The role played by adenosine triphosphate (ATP) and ATP sensitive purinergic P2X receptors will be emphasized.
摘要
外周动脉疾病（PAD）患者在运动期间，由交感神经活动（SNA）调节的动脉血压（BP）和血管收缩会增强。运动升压反射被认为是PAD患者对运动产生过度自主反应的一种神经机制。一系列研究采用了PAD大鼠模型，以在受体和细胞水平上研究运动升压反射增强的信号通路。本综述将总结近期人类和动物研究中关于肌肉传入神经对PAD中SNA增强和BP反应的贡献的结果。将重点强调三磷酸腺苷（ATP）和ATP敏感嘌呤能P2X受体所起的作用。
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