使用SperMagic培养基刺激不动精子后的临床和新生儿结局。
The clinical and neonatal outcomes after stimulation of immotile spermatozoa using SperMagic medium.
作者信息
Gu Yi-Fan, Zhou Qin-Wei, Zhang Shuo-Ping, Lu Chang-Fu, Gong Fei, Shi Yun, Lu Guang-Xiu, Lin Ge
机构信息
Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.
Reproductive & Genetic Hospital of CITIC-XIANGYA, Changsha, China.
出版信息
Andrologia. 2018 Sep;50(7):e13056. doi: 10.1111/and.13056. Epub 2018 Jun 3.
To evaluate the efficiency and safety of SperMagic medium on stimulating the immotile spermatozoa in testicular sperm extraction (TESE) and absolute asthenozoospermia, 96 patients with TESE and 106 patients with absolute asthenozoospermia were enrolled in this study. The motile spermatozoa were detected in 47 TESE patients and 68 absolute asthenozoospermia and these patients were assigned to control group. The immotile spermatozoa in 49 TESE patients and 34 absolute asthenozoospermia were stimulated with SperMagic medium. Patients were treated by standard intracytoplasmic sperm injection (ICSI). There were no significant differences in fertilisation, cleavage, implantation, pregnancy, live birth and neonatal outcomes. SperMagic medium does not increase incidence of adverse neonatal outcomes and is a reliable tool for selection of viable spermatozoa in ICSI.
为评估SperMagic培养基在睾丸精子提取术（TESE）中刺激不动精子以及在严重少弱精子症中的有效性和安全性，本研究纳入了96例接受TESE的患者和106例严重少弱精子症患者。在47例TESE患者和68例严重少弱精子症患者中检测到活动精子，这些患者被分配到对照组。对49例TESE患者和34例严重少弱精子症患者的不动精子使用SperMagic培养基进行刺激。患者接受标准的卵胞浆内单精子注射（ICSI）治疗。在受精、卵裂、着床、妊娠、活产和新生儿结局方面没有显著差异。SperMagic培养基不会增加不良新生儿结局的发生率，是ICSI中选择有活力精子的可靠工具。
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