免疫疗法诱发的甲状腺功能减退症：一例接受伊匹木单抗和纳武单抗治疗的黑色素瘤病例报告
Immunotherapy-induced hypothyroidism A report of melanoma treated by ipilimumab and nivolumab.
作者信息
Haissagerre Magalie, Prey Sorilla, Lauro Cindy, Rousset Marine, Georges Agnès, Corcuff Jean-Benoît
机构信息
Department of endocrinology, University Hospital Bordeaux, France.
Department of dermatology, University Hospital Bordeaux, France.
出版信息
Ann Biol Clin (Paris). 2018 Jun 1;76(3):326-328. doi: 10.1684/abc.2018.1350.
PMID:29862971
Abstract
We report the case of a patient treated by ipilimumab and nivolumab for a metastatic melanoma. After a mild clinical thyroiditis and a transient biological hyperthyroidism she rapidly demonstrated a peripheral hypothyroidism with appearance of antibodies against thyroperoxidase and thyroglobulin.
摘要
我们报告了一例接受伊匹单抗和纳武单抗治疗转移性黑色素瘤的患者。在出现轻度临床甲状腺炎和短暂的生化性甲状腺功能亢进后，她迅速出现了外周性甲状腺功能减退，并出现了抗甲状腺过氧化物酶和甲状腺球蛋白抗体。
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