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sn-2假说:棕榈油对血脂水平影响的综述。

sn-2 Hypothesis: a Review of the Effects of Palm Oil on Blood Lipid Levels.

作者信息

Sin Teh Soek, Ong Augustine Soon Hock, Choo Yuen May, Mah Siau Hui

机构信息

Engineering and Processing, Malaysian Palm Oil Board, 6, Persiaran Institusi.

Malaysian Oil Scientists' and Technologists' Association (MOSTA).

出版信息

J Oleo Sci. 2018;67(6):697-706. doi: 10.5650/jos.ess18009.

DOI:10.5650/jos.ess18009
PMID:29863090
Abstract

Saturated fats are commonly claimed to raise human blood cholesterols and contribute to cardiovascular disease. Previous literature data were highlighted that although palm oil is 50% saturated, it does not behave like a saturated fat. Human trials were conducted to compare the effects on serum cholesterol levels given by palm olein and monounsaturated oils. It was postulated that saturation/unsaturation of the fatty acids situated at sn-2 positions of triglycerides in the fat molecules determine the induced blood lipid levels but not the overall saturation of oils. The results showed that the lipid parameters (LDL and HDL) effects induced by these oils are similar with no significant differences. This study provides concrete evidence that the unsaturation levels of these oils at sn-2 position of TG are similar (90-100%) which are claimed to be responsible for the lipid parameters. In conclusion, the public negative perception on believing that the overall saturation of oils is detrimental to health should be corrected because in fact the unsaturation at sn-2 positions of the saturated vegetable fat such as palm olein and cocoa butter make them behave like mono-unsaturated oils, unlike saturated animal fats that possess a high content of saturated fatty acids at sn-2 position.

摘要

通常认为饱和脂肪会升高人体血液胆固醇水平并导致心血管疾病。先前的文献数据强调,尽管棕榈油的饱和脂肪酸含量为50%,但其表现并不像饱和脂肪。进行了人体试验,以比较棕榈油精和单不饱和油对血清胆固醇水平的影响。据推测,脂肪分子中甘油三酯sn-2位脂肪酸的饱和/不饱和程度决定了所诱导的血脂水平,而不是油的总体饱和度。结果表明,这些油所诱导的脂质参数(低密度脂蛋白和高密度脂蛋白)效应相似,无显著差异。本研究提供了具体证据,表明这些油在甘油三酯sn-2位的不饱和程度相似(90-100%),据称这是导致脂质参数变化的原因。总之,公众认为油的总体饱和度对健康有害的负面看法应该得到纠正,因为事实上,像棕榈油精和可可脂这样的饱和植物脂肪在sn-2位的不饱和程度使其表现得像单不饱和油,这与在sn-2位含有高含量饱和脂肪酸的饱和动物脂肪不同。

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Nutrients. 2024 Mar 27;16(7):973. doi: 10.3390/nu16070973.
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Balancing functional and health benefits of food products formulated with palm oil as oil sources.平衡以棕榈油为油源配制的食品的功能和健康益处。
Heliyon. 2022 Oct 11;8(10):e11041. doi: 10.1016/j.heliyon.2022.e11041. eCollection 2022 Oct.
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Effects of Palm Stearin versus Butter in the Context of Low-Carbohydrate/High-Fat and High-Carbohydrate/Low-Fat Diets on Circulating Lipids in a Controlled Feeding Study in Healthy Humans.
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Nutrients. 2021 Jun 5;13(6):1944. doi: 10.3390/nu13061944.
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Palm Oil on the Edge.棕榈油的困境
Nutrients. 2019 Aug 26;11(9):2008. doi: 10.3390/nu11092008.
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The palm oil industry and noncommunicable diseases.棕榈油产业与非传染性疾病。
Bull World Health Organ. 2019 Feb 1;97(2):118-128. doi: 10.2471/BLT.18.220434. Epub 2018 Jan 8.