己酮可可碱对血小板聚集和血栓素合成的影响。

Effect of cetiedil on platelet aggregation and thromboxane synthesis.

作者信息

Yamaguchi A, Asakura T, Tanoue K, Yamazaki H

出版信息

Thromb Res. 1985 Feb 1;37(3):391-400. doi: 10.1016/0049-3848(85)90068-4.

Abstract

Cetiedil was found to inhibit platelet aggregation and thromboxane synthesis induced by thrombin and arachidonic acid. When platelets were activated by thrombin, half maximal inhibition (ED50 effective dose of cetiedil necessary for 50% inhibition) for platelet aggregation was 100 microM while that for thromboxane B2 (TXB2) production was 50 microM. When arachidonic acid was used, the ED50 for platelet aggregation was 100 microM while that for TXB2 production was 150 microM. The presence of calcium ions did not affect on the inhibitory effects of cetiedil. The cAMP level in platelets did not increase after incubation with cetiedil. Cetiedil appears to inhibit the activation of platelets related to thromboxane synthesis.

摘要

已发现西替地尔可抑制由凝血酶和花生四烯酸诱导的血小板聚集和血栓素合成。当血小板被凝血酶激活时，西替地尔对血小板聚集的半数最大抑制浓度（ED50，即50%抑制所需的西替地尔有效剂量）为100微摩尔，而对血栓素B2（TXB2）生成的半数最大抑制浓度为50微摩尔。当使用花生四烯酸时，西替地尔对血小板聚集的ED50为100微摩尔，而对TXB2生成的ED50为150微摩尔。钙离子的存在不影响西替地尔的抑制作用。血小板与西替地尔孵育后，其环磷酸腺苷（cAMP）水平未升高。西替地尔似乎抑制与血栓素合成相关的血小板激活。