School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, China.
ChemMedChem. 2018 Aug 10;13(15):1490-1507. doi: 10.1002/cmdc.201800253. Epub 2018 Jun 26.
Cancer is one of the leading causes of human mortality globally; therefore, intensive efforts have been made to seek new active drugs with improved anticancer efficacy. Indazole-containing derivatives are endowed with a broad range of biological properties, including anti-inflammatory, antimicrobial, anti-HIV, antihypertensive, and anticancer activities. In recent years, the development of anticancer drugs has given rise to a wide range of indazole derivatives, some of which exhibit outstanding activity against various tumor types. The aim of this review is to outline recent developments concerning the anticancer activity of indazole derivatives, as well as to summarize the design strategies and structure-activity relationships of these compounds.
癌症是全球导致人类死亡的主要原因之一；因此，人们已经做出了巨大努力，以寻求具有更好抗癌效果的新型活性药物。含吲唑的衍生物具有广泛的生物学特性，包括抗炎、抗菌、抗 HIV、抗高血压和抗癌活性。近年来，抗癌药物的发展产生了多种吲唑衍生物，其中一些对各种肿瘤类型具有突出的活性。本文综述了吲唑衍生物的抗癌活性的最新研究进展，并对这些化合物的设计策略和构效关系进行了总结。
